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CNS Pharmacology Exam Questions Set | 474 Questions With 100% Correct Answers| Verified
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CNS Pharmacology Exam Questions Set | 474 Questions With 100% Correct Answers| Verified
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CNS Pharmacology Exam Questions Set |474 Questions With 100% Correct
Answers| Verified
What are the manifestations of serotonin syndrome - ANSWER - Muscle rigidity
- Myoclonus
-Hyperthermia
- CNS stimulatory effects such as seizures
- Cardiovascular instability
What are some drugs associated with serotonin syndrome - ANSWER - St. jhons wort
- MOAI
,- Dextromethorphan
-MDMA
- TCA
- meperidine
What is a non-selective serotonin norepinephrine reuptake inhibitor - ANSWER TCA
What antidepressant is metabolized by ONLY CYP2D6 - ANSWER Venlafaxine
What is the active metabolite of venlafaxine - ANSWER Desvenlafaxine
What antidepressantS has the lowest protein binding OF ALL - ANSWER Venlafaxine
and Desvenlafaxine
What antidepressant is dosed once daily even though the half-life is 12-15 hours? - ANSWER
Duloxetine
True or False: Duloxetine is not extensively bound to plasma proteins - ANSWER False (97%
bound to plasma proteins)
What antidepressant is metabolized by BOTH CYP2D6 and CYP1A2 - ANSWER Duloxetine
What is Milnacipran - ANSWER a SNRI
How do SNRI block the transporter - ANSWER Allosterically
,Other than norepinephrine, what neurotransmitter has an affinity to NET? - ANSWER Dopamine
True or False: Desvenlafaxine, milnacipran, levomilnacipran and duloxetine have weak NET
inhibition - ANSWER False (only venlafaxine has weak NET affinity the rest have more balanced
affinity to both SERT and NET)
True or False: SNRI tend to have higher affinity to NET than SERT - ANSWER False
Which SNRI increases blood pressure? - ANSWER Venlafaxine
Which SNRI increases heart rate? - ANSWER Venlafaxine
What are the side effects of SNRI - ANSWER -Increased heart rate and blood pressure
(mainly venlafaxine)
- CNS activation
- Insomnia
-Anxiety
-Agitation
True or False: Duloxetine is always associated with hepatic toxicity in patients with liver
damage - ANSWER False (it is RARELY associated)
True or False: ALL SNRI have been associated with discontinuation syndrome - ANSWER True
, True or False: Minor changes in chemical structure of TCA causes substantial change in their
pharmacological action - ANSWER True
What antidepressant class has poor tolerability, lethality with overdose, and difficulty of use? -
ANSWER TCA
What are the metabolic pathways of TCA - ANSWER - Demethylation (Major)
- Aromatic hydroxylation
- glucuronide conjugation
All TC antidepressants are metabolized by - ANSWER CYP2D6 and CYP3A4
What SSRI increases levels of TCA - ANSWER Fluoxetine
True or False: 5% of TCA are excreted unchanged in the urine - ANSWER True
What TCA have a wide therapeutic window - ANSWER Desipramine and nortriptyline (since they
have no active metabolites they exert linear pharmacokinetics)
What is the most protein bound TCA - ANSWER clomipramine
Why do TCA cause dry mouth and constipation - ANSWER They have antimuscarinic activity
What class of antidepressants cause orthostatic hypotension - ANSWER TCA ( They block alpha
1 receptors)
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