Pharmacokinetics - answer What the BODY does to the DRUG
Pharmacodynamics - answer What the DRUG does to the BODY
1. Absorption
2. Distribution
3. Metabolism
4. Elimination - answer Pharmacokinetic properties determining the onset, intensity, and
duration of drug action.
Absorption - answer From the site of administration, permits entry of the drug (either
directly or indirectly) into plasma.
Distribution - answer The drug may reversibly leave the bloodstream and distribute into
the interstitial and intracellular fluids.
Metabolism - answer The drug may be bio transformed through metabolism by the liver
or other tissues.
Elimination - answer The drug and its metabolites are eliminated from the body in urine,
bile, or feces.
Enteral ROA - answerAdministration by mouth. The most common, convenient, and
economical method of drug administration.
Oral ROA - answerEasily self-administered, and toxicities and/or overdose may be
overcome with antidotes, such as activated charcoal.
Disadvantage of Oral ROA - answerPathways involved are the most complicated, and
the low gastric pH inactivates some drugs.
Enteric-coated Preparations - answerChemical envelope that protects the drug from
stomach acid, delivering it instead to the less acidic intestine, where the coating
dissolves and releases the drug.
Advantage of Enteric-coated Preparations - answerUseful for acid labile and drugs that
are irritating to the stomach (i.e. aspirin).
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