Exam (elaborations)
Pharmaceutical toxicology Questions with Correct Answers.
- Course
- Institution
Pharmaceutical toxicology Questions with Correct Answers.
[Show more]
Content preview
Pharmaceutical toxicology Questions with CorrectAnswers
Define the following terms:
a) Toxicology
b) Poison
c) Toxin
d) Toxicant
e) Toxicity Correct Answer-a) The study of adverse effects of various
agents causing toxicity on living organism
b) Substance causing harm, injury or death to a living organism
c) Naturally biosynthesised poison (e.g. Bacteria, fungi, animal source or
plants)
d) Toxicant = Toxins or poisons (toxic substance)
e) Measure of adverse effects induced by a toxicant
What are 2 parameters that determine in vivo toxicity? Correct Answer--
Toxicokinetics (ADME)
- Bioavailbility to toxicant
,In relation to the 2 parameters of toxicokinetics and bioavailability of
toxicant, what are the 5 factors that influence theses parameters
associated with toxicity from the toxicant? Correct Answer-1) Nature
and properties of toxicant
- e.g. Functional groups, degree of solubility and ionisation of drug can
alter the degree of toxicity (e.g. CNS toxicity if lipophilic)
2) Dose of toxicant
- e.g. Higher dose of toxicant = Increased toxicity
3) Route of exposure of toxicant
- e.g. Oral toxicants < IV toxicants (due to oral dosage undergoing
metabolic detoxfication and degradation = Decreased systemic
absorption)
4) Health status of individual
- e.g. Immunocompromised, obesity or diabetes can worsen the toxicity
effects from the toxicant.
5) Genetic make-up of the individual
- e.g. Polymorphism of individual, may not have sufficient metabolic
enzymes to detoxify the toxicant, increasing toxicity.
What is the KEY toxiolgoical concept? Correct Answer-The DOSE
makes the poison (e.g. NaCl - Harmless at low levels, very harmful at
higher levels).
, - All substances are poisons, the right dose differentiates between
toxicity or therapeutic effects.
List some examples of common toxicants? Correct Answer-1)
Therapeutic drugs
2) Toxins:
- Animal toxins
- Fungi toxins
- Microbial toxins
- Plant toxins
3) Food additives
4) Environment pollution
5) Pesticides
6) Industrial/household agents
What is the most common cause of toxicity? Accidental or conscious?
Correct Answer-Most causes of toxicity is due to accidental exposure to
a toxicant product.
What are the factors that determine whether a patient decides to
consciously expose themselves to toxicity? Correct Answer-Individuals
who purposely exposure themselves to toxicity, often undergoes a risk-
vs-benefits decision factoring the following:
1) Type of drug
2) Disease state
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller cracker. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
80364 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now