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BLOCK 3 PMY 302 - DRUGS to KNOW Exam Study Guide with Complete Solutions
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BLOCK 3 PMY 302 - DRUGS to KNOW Exam Study Guide with Complete Solutions Somatropin Drug Class - Answer️️ -Synthetic recombinant human growth hormone Somatropin MOA - Answer️️ -Identical in action and abilities like endogenous secreted GH (stimulating proliferation of bone growth plate...

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  • September 1, 2024
  • 35
  • 2024/2025
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©SOPHIABENNETT
2024-2025 ACADEMIC YEAR EXAM SERIES




©SOPHIABENNETT 9/1/24 2024/2025

,BLOCK 3 PMY 302 - DRUGS to KNOW
Exam Study Guide with Complete
Solutions

Somatropin Drug Class - Answer✔️✔️-Synthetic recombinant human growth hormone


Somatropin MOA - Answer✔️✔️-Identical in action and abilities like endogenous secreted

GH (stimulating proliferation of bone growth plates and increased linear bone growth,

promotion of protein synthesis throughout the body)

Somatropin/Somatrem dosing - Answer✔️✔️-Daily dosing dependent and adjusted to

individual clinical response and IGF-1 levels

Somatropin/Somatrem pharmacokinetics - Answer✔️✔️-Following SC injection, 80% of

the drug will be systemically available

Somatropin/somatrem results and monitoring - Answer✔️✔️-Response to GH therapy is

measured every 3-6 months by height and bone age determinations

Somatropin/Somatrem Therapeutic use - Answer✔️✔️-Childhood Dwarfism/Growth

hormone deficiency disorders

Somatrem Drug class - Answer✔️✔️-Analog of GH; synthetic recombinant human growth

hormone with Extra amino acid noted in protein makeup

Somatrem MOA - Answer✔️✔️-Similar to somatropin

Octreotide Acetate and Lanreotide drug class - Answer✔️✔️-synthetic analogs of

somatostatin



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,Octreotide Acetate and Lanreotide MOA - Answer✔️✔️-acts identical to somatostatin to

directly inhibit GH release from the anterior pituitary which effectively decreases

circulating GH and IGF-1 levels

Octreotide Acetate and Lanreotide Dosing - Answer✔️✔️-Long-acting depots allow for

once-a-month IM dosing due to gradual release formula (10-20 mg/4 weeks) T ½: 1-2

hours

Octreotide Acetate and Lanreotide Therapeutic effects - Answer✔️✔️-suppresses GH

hypersecretions, reduces pituitary adenoma overgrowth, and normalizing levels of GH

and IGF-1

Octreotide acetate/Lanreotide/Pegvisomant Use - Answer✔️✔️-Acromegaly/Gigantism Tx

Pegvisomant Drug class - Answer✔️✔️-GH receptor antagonist

Pegvisomant MOA - Answer✔️✔️-Blocks actions of GH and reduces the levels of

circulating IGF-1

Pegvisomant Dosing - Answer✔️✔️-daily SubQ injections; increases dose until serum

IGF-1 levels are maintained to be within the age-appropriate/normal range (usually

within 12 months, pt. Will have normal or next to normal levels of IGF-1)

Pegvisomant drug structure - Answer✔️✔️-Extremely similar protein structure to GH but

acts as a receptor antagonist

Bromocriptine/Cabergoline drug class - Answer✔️✔️-Dopamine Receptor Agonists

Bromocriptine/Cabergoline MOA - Answer✔️✔️-Decreases prolactin production and

secretions by prolactin-secreting pituitary tumors; mimics the actions of dopamine and

causes inhibition of prolactin secretion

Page 2 of 34

, Bromocriptine/Cabergoline Pharmacokinetics - Answer✔️✔️-Orally Active and effective

use in 80-85% of cases

Bromocriptine/Cabergoline Therapeutic effects - Answer✔️✔️-Reduces tumor size,

suppresses galactorrhea and restores normal ovulatory menstrual cycles

Bromocriptine special consideration - Answer✔️✔️-Longer track record of safety in use

and cheaper to produce (DOC/more commonly used)

Cabergoline special consideration - Answer✔️✔️-Has higher reported affinity for D2

receptors

Desmopressin Drug Class - Answer✔️✔️-DDAVP/Vasopressin synthetic analog

Desmopressin MOA - Answer✔️✔️-activates V2 receptors in the kidney's collecting ducts,

reabsorbing water into plasma and concentrating the urine (prevents water from leaving

the body)

Desmopressin compared to ADH - Answer✔️✔️-Longer noted serum T ½ compared to

ADH (DDAVP t ½ = 75 min) (ADH t ½ = >10 min)

Desmopressin Structure - Answer✔️✔️-Almost identical to ADH except for D-Amino acid

in chemical chain sequence (ADH has L-Amino Acid) *NOTE: Has a greater selectivity

for V2 receptors compared to typical ADH*

Desmopressin Pharmacokinetics - Answer✔️✔️-Extremely potent drug; Tablet (0.1-0.2

mg) or nasal spray (0.01mg)

Desmopressin Outcomes of DI - Answer✔️✔️-Excessive urine production controlled with

0.1mg/3x daily




Page 3 of 34

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