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DRUGS to KNOW: BLOCK 3 PMY 302; Questions and Answers 100% Solved

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DRUGS to KNOW: BLOCK 3 PMY 302; Questions and Answers 100% Solved Somatropin Drug Class CORRECT ANS-Synthetic recombinant human growth hormone Somatropin MOA CORRECT ANS-Identical in action and abilities like endogenous secreted GH (stimulating proliferation of bone growth plates and increase...

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  • September 1, 2024
  • 65
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers

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  • drugs to know block 3 pmy 302
  • questions and answers 100 solved

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  • PMY 302
  • PMY 302

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DRUGS to KNOW: BLOCK 3 PMY 302; Questions
and Answers 100% Solved

Somatropin Drug Class CORRECT ANS-Synthetic recombinant human growth hormone




Somatropin MOA CORRECT ANS-Identical in action and abilities like endogenous secreted

GH (stimulating proliferation of bone growth plates and increased linear bone growth,

promotion of protein synthesis throughout the body)




Somatropin/Somatrem dosing CORRECT ANS-Daily dosing dependent and adjusted to

individual clinical response and IGF-1 levels




Somatropin/Somatrem pharmacokinetics CORRECT ANS-Following SC injection, 80% of the

drug will be systemically available




Somatropin/somatrem results and monitoring CORRECT ANS-Response to GH therapy is

measured every 3-6 months by height and bone age determinations




Somatropin/Somatrem Therapeutic use CORRECT ANS-Childhood Dwarfism/Growth

hormone deficiency disorders

, DRUGS to KNOW: BLOCK 3 PMY 302; Questions
and Answers 100% Solved


Somatrem Drug class CORRECT ANS-Analog of GH; synthetic recombinant human growth

hormone with Extra amino acid noted in protein makeup




Somatrem MOA CORRECT ANS-Similar to somatropin




Octreotide Acetate and Lanreotide drug class CORRECT ANS-synthetic analogs of

somatostatin




Octreotide Acetate and Lanreotide MOA CORRECT ANS-acts identical to somatostatin to

directly inhibit GH release from the anterior pituitary which effectively decreases circulating

GH and IGF-1 levels




Octreotide Acetate and Lanreotide Dosing CORRECT ANS-Long-acting depots allow for

once-a-month IM dosing due to gradual release formula (10-20 mg/4 weeks) T ½: 1-2 hours

, DRUGS to KNOW: BLOCK 3 PMY 302; Questions
and Answers 100% Solved

Octreotide Acetate and Lanreotide Therapeutic effects CORRECT ANS-suppresses GH

hypersecretions, reduces pituitary adenoma overgrowth, and normalizing levels of GH and

IGF-1




Octreotide acetate/Lanreotide/Pegvisomant Use CORRECT ANS-Acromegaly/Gigantism Tx




Pegvisomant Drug class CORRECT ANS-GH receptor antagonist




Pegvisomant MOA CORRECT ANS-Blocks actions of GH and reduces the levels of circulating

IGF-1




Pegvisomant Dosing CORRECT ANS-daily SubQ injections; increases dose until serum IGF-1

levels are maintained to be within the age-appropriate/normal range (usually within 12

months, pt. Will have normal or next to normal levels of IGF-1)




Pegvisomant drug structure CORRECT ANS-Extremely similar protein structure to GH but

acts as a receptor antagonist

, DRUGS to KNOW: BLOCK 3 PMY 302; Questions
and Answers 100% Solved


Bromocriptine/Cabergoline drug class CORRECT ANS-Dopamine Receptor Agonists




Bromocriptine/Cabergoline MOA CORRECT ANS-Decreases prolactin production and

secretions by prolactin-secreting pituitary tumors; mimics the actions of dopamine and causes

inhibition of prolactin secretion




Bromocriptine/Cabergoline Pharmacokinetics CORRECT ANS-Orally Active and effective

use in 80-85% of cases




Bromocriptine/Cabergoline Therapeutic effects CORRECT ANS-Reduces tumor size,

suppresses galactorrhea and restores normal ovulatory menstrual cycles




Bromocriptine special consideration CORRECT ANS-Longer track record of safety in use and

cheaper to produce (DOC/more commonly used)

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