Endocrine Disorders I NURS 5315 Test 4
The uptake of iodine is regulated by
TSH
How are T3 and T4 stored?
thyroglobulin (TG); which is a precursor to both hormones
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How long will a person have a failed thyroid prior to manifesting any symptoms?
2-3 months
Functions of T3 and T4
maintenance of muscle tone
skeletal muscle maturation
antagonization of insulin
regulation of cellular metabolism
promotion of the production of heat
maintenance of cardiac output, contraction and rate maintenance of GI secretion
assistance with calcium mobilization and stimulation of lipid metabolism
free fatty acid release
cholesterol synthesis
RBC production
regulates body heat production
affects respiratory rate and oxygen utilization.
, The production of the contractile protein α-myosin heavy chain is stimulated by
T3 in the heart
T3 also stimulates the production of
the sarcolemma ion pumps (Na+ -K + ATPase pump, Ca++ ATPase pump) and the β-adrenergic
receptor
Concerning heart failure, hyperthyroidism may
increase the heart rate, cardiac output and cause cardiomyopathy
Calcitonin is secreted by
the C-cells of the thyroid
Calcitonin functions to
lower serum calcium by preventing the bone resorption effects of PTH, prostaglandins and
calciferols by blocking osteoclastic activity
Calcitonin is also responsible for
lowering serum phosphate levels and decreasing GI absorption of calcium and phosphorus.
Hyperthyroidism is a condition which results in the
over-secretion of thyroid hormone
The over-secretion of thyroid hormone can be caused by
Grave's disease, thyroid cancer, or thyroid nodules
Clinical manifestations of hyperthyroidism
are a direct result of the effect of the increased circulating thyroid hormone levels
In hyperthyroidism, metabolic rate increases which causes
a heat intolerance
Additional clinical manifestations of hyperthyroidism are
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