BCH 361 CHAPTER 18 TEST QUESTIONS WITH ALL CORRECT ANSWERS
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Course
BCH 361
Institution
BCH 361
BCH 361 CHAPTER 18 TEST QUESTIONS WITH ALL CORRECT ANSWERS
Assume that in a cell the ratio listed is high. Which ratio(s) would lead to a decrease in the rate of entrance of acetyl CoA into the citric acid cycle? - NADH/NAD+
Which of the following statements is TRUE regarding the mechanism of ...
BCH 361 CHAPTER 18 TEST
QUESTIONS WITH ALL CORRECT
ANSWERS
Assume that in a cell the ratio listed is high. Which ratio(s) would lead to a decrease in
the rate of entrance of acetyl CoA into the citric acid cycle? - NADH/NAD+
Which of the following statements is TRUE regarding the mechanism of pyruvate
dehydrogenase complex? - A carbanion is formed on TPP following the release of H+
The blue lysine side chain shown here is part of the structure of: - dihydrolipoyl
transacetylase
Although symptoms of beriberi are similar to those seen with mercury exposure, beriberi
affects the _____ subunit of pyruvate dehydrogenase complex, while mercury exposure
affects the _____ subunit. - E1; E3
A mutant pyruvate dehydrogenase complex is generated in the lab in which the
lipoamide is linked to the amide backbone group of E2 directly at a similar location as
the wild-type enzyme. Which of the following statements is likely TRUE of such a
mutant? - The mutant will initially be able to decarboxylate pyruvate, but the reaction will
not proceed past this point
The protein environment of dihydrolipoyl dehydrogenase is important in the function of
the complex because it: - increases the electron-transfer potential of FAD
Beriberi involves a reduction in the activity of pyruvate dehydrogenase complex. Which
enzyme(s) in the complex is/are specifically affected in this disease through loss or
reduction of a prosthetic group? - pyruvate dehydrogenase component (E1)
When pyruvate initially binds to the pyruvate dehydrogenase complex, which of the
following statements is TRUE? - The cofactor of E3 is in its reduced form
Which of the following is NOT a coenzyme necessary in the function of pyruvate
dehydrogenase complex?
a. thiamine pyrophosphate (TPP)
b. FAD
c. lipoic acid
d. NAD+
e. ubiquinone - e. ubiquinone
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