HAM side effects: - ANSWER-1. anti-Histamine: sedation, weight gain
2. anti-Adrenergic: hypotension
3. anti-Muscarinic: dry mouth, blurred vision, urinary retention
In which medications do you see HAM side effects? - ANSWER-TCAs
and low-potency antipsychotics
What is Serotonin Syndrome? - ANSWER-Confusion
Flushing, Diaphoresis, Hyperthermia
Tremor
Hypertonicity, Rhabdomyolysis, Renal failure
Death
When does Serotonin Syndrome occur? - ANSWER-Classically when
SSRIs and MAOIs are combined
What causes a hypertensive crisis? - ANSWER-Buildup of stored
catecholamines: MAOIs + foods with Tyramine or/+
Sympathomimetics
What are Extrapyramidal Side Effects? - ANSWER-1. Parkinsonism
2. Akathisia
3. Dystonia
,EPS traditionally occur with which class of medications? - ANSWER-
High Potency traditional antipsychotics
EPS occur within what time frame of starting meds? - ANSWER-
Within days
EPS can be life threatening, why? - ANSWER-Dystonia of
diaphragm=Asphyxia
Choice drug to treat EPS produced by neuroleptics is? - ANSWER-
Benztropine/Cogentin
Hyperprolactinemia occurs with what meds? - ANSWER-High potency
traditional antipsychotics and risperidone
Tardive dyskinesia is? - ANSWER-Choreoathetoid muscle
movements, usually of mouth and tongue. Occurs YEARS after
antipsychotic use. Can be irreversible. Looks like grimacing and
tongue protrusion.
What is Neuroleptic Malignant Syndrome? - ANSWER-Fever, Tachy,
Hypertension, Tremor
Elevated CPK
Lead pipe rigidity
, NMS can be caused by? - ANSWER-Caused by antipsychotics after
short or long term. MED EMERGENCY with 20% mortality rate
What are common CYP450 enzymes important in metabolizing
psychiatric drugs? - ANSWER-CYP1A2
CYP2C9, CYP2C19
CYP2D6 CYP3A4
CYP450 Inducers: decreases level of drugs in the system due to
"Inducing metabolism," include: - ANSWER-Smoking (1A2)
Carbamezipine (1A2, 2C9, 3A4)
Barbiturates (2C9)
St. John's Wort (2C19, 3A4)
Anticholinergics are known to exacerbate what disease? - ANSWER-
Alzheimer's disease
Fluoxetine (Prozac): - ANSWER-1. longest half-life: no need to taper
2. safe in pregnancy
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller nyagajoseph539. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $18.49. You're not tied to anything after your purchase.
