©SOPHIABENNETT@2024-2025 Sunday, August 25, 2024 2:42 PM
Vanderbilt University School of Nursing
VUSN pharm exam 3 Study Guide with
Complete Solutions
Cholestyramine - Answer✔️✔️-statin
Action: reduces LDL
binds with bile salt in intestines --> bile acids + cholesterols are eliminated
in feces
adverse effects: constipation, bloating, belching, esophageal irritation &
obstruction
Fibric Acid Derivatives - Answer✔️✔️-gemfibrozil
use: reduces VLDL & triglycerides
action: inhibits breakdown of stored fats, uptake of fatty acids, triglyceride
production
adverse effects: N/V, cholelithiasis, inc INR w/ warfarin, GI comp
Nicotinic Acid - Answer✔️✔️-niacin
use: reduces VLDL & LDL, triglycerides
action: inhibits release of free fatty acids, increased lipoprotein lipase
activity
Side effects: flushing, itching, stimulation of prostaglandins, GI intolerance,
myalgia
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, ©SOPHIABENNETT@2024-2025 Sunday, August 25, 2024 2:42 PM
Vanderbilt University School of Nursing
*take aspirin before morning dose
HMG - CoA reductase inhibitors - Answer✔️✔️-Rosuvastatin
action: inhibition of HMG-CoA reductase, reduces cholesterol synthesis &
LDL
*nocturnal dosing
adverse effect: GI distress, rhabdomyolysis
*discontinue in cases of: muscle pain, weakness, fatigue, fever
monitor CK labs
interactions: grapefruit, pomegranates
beta blocker metoprolol - Answer✔️✔️-use: HTN, chest pain, post MI,
dysthymias, HF
action: block B1, <B2, decrease HR & contractility, decrease renin, decrease
PVR
*negative chronotrope, isotrope
routes: PO, IR, SR, IV, ophthalmologic
contra: DM, chronic lung disease, HF on Dig, hyperthyroid, bradycardia,
2nd degree HB or greater, < 6yo
interact: other antihypertensives, digoxin (increase bradycardia),
neuromuscular, blocking agents
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