PCB 3233 Immunology Exam 4 Practice
Questions and Answers
Positive Selection - Answer️️ -makes sure that your T-Cell
recognizes one of your MHC.
If it does not, then apoptosis
Negative Selection - Answer️️ -Makes sure it does not recognize
your peptide:MHC too strongly
Does gamma: de...
Notch-1 - Answer✔️✔️-The signal for survival. It drives the cell on the
T-cell path — signals to open up T-cell rearrangement.
Signaling rearrangement keeps T-cel on T-cell pathway
Where does Maturation and Positive Selection occur? - Answer✔️✔️-
Cortex of the thymus
Can negative selection also take place in the Cortex? - Answer✔️✔️-
Yes, negative selection can take place in the cortex at the same time
as positive selection
Where does negative selection take place? - Answer✔️✔️-medulla of
thymus
Where are mature thymocytes located? - Answer✔️✔️-Medulla
Where are immature thymocytes located? - Answer✔️✔️-Cortex
What special cells are in the Medulla - Answer✔️✔️-Dendritic cells,
macrophages, and medullary epithelial cells
What special cells are in the cortex? - Answer✔️✔️-Cortical epithelial
cells and macrophages
Where can you find AIRE? - Answer✔️✔️-in the medullary epithelial
cells
Creates a couple hundred peripheral peptides that can be used to
test T-cells for negative selection
DiGeorge's syndrome - Answer✔️✔️-deletion in chromosome 22 in
which thymus fails to develop and T-cells are absent
Hassall's corpuscles - Answer✔️✔️-macrophages in both cortex and
medulla remove the many thymocytes that fail to mature properly
Involution of the Thymus - Answer✔️✔️-Progressively shrinks, fat
gradually claiming areas once packed with thymocytes
-reduces production of new T-cells
Double negative - Answer✔️✔️-No CD4 and CD8
Double Positive - Answer✔️✔️-CD4 and CD8 are present
Single Positive - Answer✔️✔️-has either CD4 or CD8
CD2 and CD5 - Answer✔️✔️-perform adhesion and signaling. They
are present during double negative stage
3
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