©THEBRIGHT EXAM STUDY SOLUTIONS 8/26/2024 11:32 AM
VUSN Pharm 2 Final Exam (Week 12)
Questions With Correct Answers
Cyclosporine, prednisone, mycophenolate, IgG - answer✔✔immunosuppressant prototype drugs
organ transplant introduces foreign tissue to body, immune system produces IL-2 (type of
lymphokine), activation of immune system leads to destruction and rejection of foreign tissue -
answer✔✔body's response to organ transplant
IL-2 - answer✔✔specific lymphokine produced by immune system when organ transplant occurs
used to suppress immune system, prevent organ/tissue rejection, prevent tissue destruction,
autoimmune diseases - answer✔✔principals of immunosuppressant therapy
increased risk for infection and neoplasms - answer✔✔risks of immunosuppressant therapy
appropriate, overactive - answer✔✔immunosuppressants minimize effects of which immune
responses?
benefit of treatment MUST outweigh risks - answer✔✔important thing to remember when
considering immunosuppressant therapy
calcineurin inhibitor - answer✔✔cyclosporine class
whole organ transplantation (liver, kidney, heart), autoimmune conditions (rheumatoid arthritis,
psoriasis) - answer✔✔cyclosporine use
inhibits calcineurin (suppresses T-cell proliferation), inhibit production and release of IL-2 -
answer✔✔cyclosporine ETA
increase levels:
- "azole" antifungals, macrolide antibiotics, Amp-B, grapefruit juice
decrease levels:
- phenytoin, phenobarbital, carbamazepine, rifampin, terbinafine, trimethoprim/sulfamethoxazole
- answer✔✔cyclosporine interactions
nephrotoxicity (75%), infection (75%), hirsutism, HTN, gingival hyperplasia, tumor, anemias (s/t
suppression of bone marrow) - answer✔✔cyclosporine side effects
, ©THEBRIGHT EXAM STUDY SOLUTIONS 8/26/2024 11:32 AM
foods to avoid (don't take w food, decreases absorption), proper med admin (same time daily),
warning s/sx of potential problems - answer✔✔cyclosporine client education
assess for allergies and contraindications, assess for baseline organ function (kidney, liver -
LFTs, electrolyte levels), assess for active infection/recent viral infection, monitor CBC for
possible bone marrow suppression (Hct, Hgb), admin at same time daily as indicated, ensure
drug levels are drawn just prior to admin - answer✔✔cyclosporine nursing interventions
corticosteroid - answer✔✔prednisone class
autoimmune disorders (idiopathic thrombocytopenia purpura), organ transplantation (Renal,
liver, bone marrow, heart), acute inflammatory processes (arthritis caused by acute
inflammation, allergic reactions, asthma) - answer✔✔prednisone use
daily weights, BP, whole blood glucose, check electrolytes (creatinine, sodium, potassium),
WBC, monitor bone density, monitor adrenal insufficiency - answer✔✔prednisone nursing
interventions
suppresses migration of leukocytes, inhibits mitosis of lymphocytes, reduces lymphatic system
activity, inhibit production of inflammatory mediators (leukotrienes, prostaglandins, histamines,
bradykinins) - answer✔✔prednisone ETA
skin thinning, infection, bone dissolution, impaired growth, adrenal insufficiency, increased
water retention, polydipsia, increased glucose - answer✔✔prednisone side effects
cytotoxic agent - answer✔✔mycophenolate class
severe refractory rheumatoid arthritis, lupus, multiple sclerosis, psoriasis, whole organ
transplantation (heart, kidney, liver) - answer✔✔mycophenolate use
destroys B and T lymphocytes, non-specific, thus toxic to all proliferating cells (goal is to reduce
antibodies in system) - answer✔✔mycophenolate ETA
antacids!, cholestyramine (both decrease effectiveness) - answer✔✔mycophenolate interactions
monitor CBC! (checking for neutropenia, thrombocytopenia, anemia), educate on GI effects,
BNP, cholesterol levels, give meds as indicated, assess and educate for s/sx of infection -
answer✔✔mycophenolate nursing interventions
bone marrow suppression (neutropenia, thrombocytopenia, anemia), GI disturbances (nausea,
diarrhea), alopecia, infection/sepsis, neoplasms (skin, lymphomas) - answer✔✔mycophenolate
side effects
antibody - answer✔✔IgG class
