,Autocrine - Answer: Communication within the same cell
Paracrine - Answer: Communication between local cells
Endocrine - Answer: Communication between remote cells
Functions of the endocrine system - Answer: Differentiation of the reproductive and central nervous
system in the developing fetus
Stimulation of sequential growth and development during childhood and adolescence
Coordination of the male and female reproductive systems
Maintenance of an optimal internal environment throughout the life span
Initiation of corrective and adaptive responses when emergency demands occur
Peptide hormones - Answer: Derived from a protein structure
Water-soluble
Synthesized and stored
Amine hormones - Answer: Derived from amino acid tyrosine-T, which is thyroid hormone T3 and T4
Steroid hormones - Answer: Fat-soluble
Come from cholesterol
Not stored, they are released as they are produced
Negative feedback - Answer: The most common homeostatic control mechanism. The net effect is that
the output of the system shuts off the original stimulus or reduces its intensity.
Think home thermostat
Water-soluble - Answer: Circulate in free unbound forms.
Short life
, E.g., insulin with a half-life of 3-5 minutes
Needs a membrane receptor to go into the cell
Lipid-soluble - Answer: Are primarily transported bound to a carrier or transport protein - can remain in
the blood for hours to days
Can go right into the cell
Target cells - Answer: Recognize and bind with a high affinity to hormones
Initiate a signal
The more receptors, the more sensitive the cell
Up-regulation - Answer: Low concentrations of hormones increase the number of receptors per cell
Down-regulation - Answer: High concentration of hormones decrease the number of receptors per cell
Prolactinoma - Answer: Anterior pituitary gland disorder that secretes prolactin.
Diabetes Insipidus (DI) - Answer: ADH deficiency decreases water reabsorption, resulting in and increase
and dilute urine output and more concentrated serum
DI S/S - Answer: Increased urine output (8 to 12 L/day)
Hypernatremia serum
Dilute urine
DI Tx - Answer: Give ADH, desmopressin (ddAVP)
Syndrome of Inappropriate Antidiuretic Hormone (SIADH) - Answer: ADH excess
Increased ADH increase water reabsorption, resulting in more concentrated urine and more dilute urine
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