SSRI Toxicity - answer✔✔SHIVERS-D
(Shivering, Hyper-reflexia, intestines, VS stability, encephalopathy, restlessness, sweating,
diarrhea)
--> Fewer than TCAs. GI distress, sexual dysfunction (anorgasmia and decreased libido).
Serotonin syndrome with any drug that increases 5-HT (e.g., MAO inhibitors, SNRIs,
TCAs)—hyperthermia, confusion, myoclonus,
cardiovascular collapse, flushing, diarrhea,
seizures. Treatment: cyproheptadine (5-HT2
receptor antagonist).
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