Hypersensitivity: Type 1 - .......🔷ANSWERS🔶......✔✔ -Mediated IgE
-inflammation due to mast cell degranultion
-anaphylactic, asthma, hay fever
treatment: epinephrine
Hypersensitivity: Type 2 - .......🔷ANSWERS🔶......✔✔ -Cytotoxic reaction: tissue specific
-binds to the antigen ON THE CELL SURFACE
-macrophages are primary effectors cells involved
cause tissue damage or alter function
Hypersensitivity 2 - .......🔷ANSWERS🔶......✔✔ -Graves Disease (hyperthyroidism) -alters function
not destroy
-blood transfusions reaction- transfused erythrocytes are destroyed by agglutination or lysis
-drug allergies
-hemolytic anemia
Hypersensitivity: type 3 - .......🔷ANSWERS🔶......✔✔ -Not organ specific
-antibody binds to soluble antigen OUTSIDE THE CELL SURFACE that was released into the blood
or bodily fluids, and the complex is then deposited in the tissues
Hypersensitivity: Type 3 - .......🔷ANSWERS🔶......✔✔ -rheumatoid arthritis
-Systemic Lupus Erythematosus (SLE)
-Raynaud's
Hives (urticaria) - .......🔷ANSWERS🔶......✔✔ Hypersensitivity Type 1
,First responders to innate the immune system - .......🔷ANSWERS🔶......✔✔ Neutrophils
Allergic contact dermatitis - .......🔷ANSWERS🔶......✔✔ Hypersensitivity Type IV
Type 2 cytotoxic hypersensitivity mediated by: - .......🔷ANSWERS🔶......✔✔ -IgG IgM
-macrophages are primary effort cells
-
Serum Sickness - .......🔷ANSWERS🔶......✔✔ type 3 hypersensitivity
Hypersensitivity IV, - .......🔷ANSWERS🔶......✔✔ -is more of a delayed immune response.
-mediated T-cells attack tissue directly (no antibodies)
Autoimmune - .......🔷ANSWERS🔶......✔✔ -diseases in which the body makes antibodies directed
against its own tissues
Renal disease associated with autoimmunity? - .......🔷ANSWERS🔶......✔✔ Glomerulonephritis
Sjogren's syndrome - .......🔷ANSWERS🔶......✔✔ Inflammation in salivary and lacrimal glands
SLE - .......🔷ANSWERS🔶......✔✔ Autoantibodies and auto-active t-cells against DNA and
nucleoprotein
Sjögren's syndrome immune changes: - .......🔷ANSWERS🔶......✔✔ Autoantibodies and auto-
reactive t-cells against apoptotic cells
rheumatoid arthritis manifestations: - .......🔷ANSWERS🔶......✔✔ Joint inflammation, stiffness,
pain, loss of range of motion
Rheumatoid Arthritis immune changes: - .......🔷ANSWERS🔶......✔✔ T-cells and B cells against
joint associated antigens
MS manifestations - .......🔷ANSWERS🔶......✔✔ Formation of sclerotic plaque in the brain, leads to
Muscle weakness and ataxia
MS immune changes - .......🔷ANSWERS🔶......✔✔ T-cells against brain antigens
___ measures the average size of RBCs - .......🔷ANSWERS🔶......✔✔ MCV
Anemia occur by... - .......🔷ANSWERS🔶......✔✔ -impaired RBC production
-excessive blood loss
- increased RBC production
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