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SBCP LIFESPAN EXAM | Questions and Answers Latest {} A+ Graded | 100% Verified
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SBCP LIFESPAN EXAM | Questions and Answers Latest {} A+ Graded | 100% Verified
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SBCP LIFESPAN EXAM | Questions and Answers Latest {2024- 2025} A+ Graded | 100%Verified
Disease states - Kidney
Liver
Acid/base imbalance
altered electrolyte status
Kidney - Responsible for the elimination of drugs via active transport Uncharge drug
↓Renal function = ↓elimination = ↑and extended plasma levels Albumin loss = less protein binding
Liver - • Major site of drug metabolism = improved renal drug excretion
• Short term: induction or inhibition of liver enzymes of liver enzymes = changed metabolism rates
• Long term (Liver damage) = ↓ rate of metabolism = ↑persistence and plasma levels
• Also ↓rate of albumin production = ↑ free drug
Acid/Base Imbalance - • Drugs designed to behave at body's normal pH
• Alterations can cause a drug to ionise - ions don't cross BBB easily
Altered Electrolyte status - • Affect physiology e.g. nerve signalling, membrane pumps
• Drug effects less common but serious
• E.g. hypokalaemia and digoxin
• Digoxin/K+ if unbalance = fatal arrhythmias
Tolerance includes - Pharmacodynamic changes
Metabolic
Pharmacodynamic changes (tolerances) - Receptor no.s on a cell are not fixed
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