Exam (elaborations)
GMS 6551 Module 3 Exam | Questions And Answers Latest {} A+ Graded | 100% Verified
- Course
- Institution
GMS 6551 Module 3 Exam | Questions And Answers Latest {} A+ Graded | 100% Verified
[Show more]
Content preview
GMS 6551 Module 3 Exam | Questions And Answers Latest {2024- 2025} A+ Graded |100% Verified
What is pharmacodynamics? - What a drug does to an organism.
What are the most common drug targets? - Receptors and enzymes.
What percentage of drug targets do receptors account for? - Almost 45%.
What percentage of drug targets do enzymes account for? - Around 28%.
What are some examples of enzyme drug targets? - Dihydrofolate reductase, Acetyl Co A reductase, and
angiotensin converting enzyme.
What are some examples of receptor drug targets? - Dopamine receptors, angiotensin receptors, and
beta adrenergic receptors.
What is the function of ion channels? - Allow for the passage of ions from or to the extracellular and
intracellular medium.
What is the function of G protein coupled receptors? - Allow for activation of various second messenger
intracellular proteins.
What is the function of kinase linked receptors? - Induce phosphorylation of various intracellular
downstream proteins.
What is the function of nuclear receptors? - Modulate gene synthesis by binding to DNA.
What is the timescale at which ion channels work? - Milliseconds.
,What is the timescale at which G protein coupled receptors work? - Seconds.
What is the timescale at which kinase linked receptors work? - Minutes.
What is the timescale at which nuclear receptors work? - Hours to days.
What are some examples of ion channels? - Nicotinic acetylcholine receptors.
What are some examples of G protein coupled receptors? - Muscarinic acetylcholine receptors.
What are some examples of kinase linked receptors? - Insulin receptors and EGF receptors.
What are some examples of nuclear receptors? - Estrogen receptors.
What are ligand gated ion channels? - Transmembrane receptors that allow passage of ions when a
ligand binds to it.
What are some examples of ligand gated ion channels? - Acetylcholine, GABA, serotonin, and glutamate
receptors.
What is the mechanism of action of drugs like nicotine and Chantix? - They bind to the ligand gated ion
channels for acetylcholine and modulate the flow of ions into the cell.
What are kinase linked receptors? - Transmembrane receptors that activate downstream signaling
molecules through kinase domains.
What are the two types of kinase linked receptors? - Tyrosine kinase coupled receptors and cytokine
receptors.
What is the mechanism of action of tyrosine kinase coupled receptors? - EGF binds to monomers, causes
dimerization, and auto phosphorylation of kinase domains, leading to activation of downstream
signaling molecules.
, What is the mechanism of action of cytokine receptors? - Cytokine binds to monomers, causes
dimerization, and activation of jak kinases, which phosphorylate intracellular domains and stats, leading
to activation of genes.
What are nuclear membrane receptors? - Transmembrane receptors found on the nuclear membrane or
inside the nucleus that activate transcription factors and induce transcription of genes.
What are the two domains of nuclear membrane receptors? - Ligand binding domain and DNA binding
domain.
What is the mechanism of action of nuclear membrane receptors? - Hormone binds to ligand binding
domain, changes receptor structure, and allows DNA binding domain to bind to DNA sequence, inducing
transcription of genes.
What are G protein coupled receptors? - Transmembrane receptors that bind to G proteins and activate
downstream effector proteins.
What is the structure of G protein coupled receptors? - They pass through the membrane seven times
and have a receptor binding pocket.
What are G proteins? - Proteins with three subunits (alpha, beta, and gamma) that use GTP as their
source of energy.
What is the mechanism of action of G protein coupled receptors? - Agonist binds to receptor binding
pocket, changes receptor structure, and allows binding to heterotrimeric G protein, leading to activation
of downstream effector proteins.
What happens when the heterotrimeric G protein is in its resting state? - It is bound to GDP and the
receptor is inactive.
What happens when the heterotrimeric G protein is in its activated state? - The alpha subunit is bound
to GTP and can activate downstream targets.
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller oneclass. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $13.48. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
67096 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now