Exam (elaborations)
UNE BIOCHEMISTRY UNIT 3
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UNE BIOCHEMISTRY UNIT 3
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UNE BIOCHEMISTRY UNIT 3ATP can be generated by many metabolic pathways in the body. Which of the following
processes generates the most ATP? - Answers -Fatty acid β-oxidation
During the fasted state, lipolysis is facilitated by the action of hormone sensitive lipase.
This enzyme requires which of the following modifications for activation? - Answers -
Phosphorylation
In the fasted state, fatty acyl-CoAs are transported across the mitochondrial membrane.
The transport of fatty acids via carnitine palmitoyl transferase I (CPTI) can be directly
inhibited by which of the following compounds? - Answers -Malonyl-CoA
A 22-year-old woman engaging in a political protest goes on a hunger strike on a
prominent corner in a city park. She refuses all offers of food except for water through
the first 2 weeks. Under these conditions there is a decreased reliance on which of the
following pathways for fuel? - Answers -Gluconeogenesis
Which of the following is not a product of β-oxidation? - Answers -NADPH
An 10-year-old boy is brought to the emergency department by his father. He reports his
son has recently been very thirsty and needing to make frequent trips to the bathroom.
Physical examination revealed a thin boy, in the 30th percentile for height and weight. A
rapid dipstick test revealed glucose in his urine. Evaluation of this boy's blood would
reveal decreased levels of which of the following compounds or hormones? - Answers -
Insulin
An individual goes to bed around 8 pm and doesn't wake up until 9 am the next
morning. During this time, which of the following is the primary oxidizable substrate in
the skeletal muscle? - Answers -Free fatty acids
In liver, which of the following key inhibitory events ensures that newly synthesized
palmitoyl-CoA is not immediately oxidized? - Answers -Inhibition of carnitine-palmitoyl
transferase-I (CPT-I) by malonyl-CoA.
During fatty acid synthesis, after the initial step involving acetyl-CoA, the fatty acid chain
is elongated by the addition of which of the following compounds? - Answers -Malonyl-
CoA
Fatty acid synthase is a multimeric enzyme complex. Which of the following subunits
contains pantothenic acid as a cofactor? - Answers -ACP (acyl carrier protein)
Under fasted condition, (glucagon is elevated), which of the following enzymes will be
phosphorylated and inactive? - Answers -HMG-CoA reductase
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