SDRIs Correct Answer -inhibit DA reuptake (↑alertness,
motivation)
-inhibit NE reuptake (↑energy)
-Adverse effects:
• agitation
• headache
• dry mouth
• constipation
• weight loss
,TCAs Correct Answer -Action: inhibits the reuptake of serotonin
and norepinephrine; blocks norepinephrine, histamine, and
acetylcholine receptors
-Examples: amitriptyline, clomipramine, desipramine, doxepin
-Common Side Effects:
• dry mouth
• constipation
• blurred vision
• urinary retention
• sedation
• weight gain
• hypotension
• tachycardia
• sexual dysfunction
MAOIs Correct Answer -Action: increases norepinephrine and
serotonin by inhibiting the enzyme that inactivates it
-Examples: isocarboxazid, phenelzine, tranylcypromine
-Common Side Effects:
• sedation
• dizziness
• sexual dysfunction
• hypertensive crisis
Prescribing pearls: sertraline (Zoloft) Correct Answer also treats
social anxiety and hypersomnolence
Prescribing pearls: bupropion (Wellbutrin) Correct Answer NDRI
may improve energy, alertness, and motivation; not first line
treatment for anxiety; contraindicated in clients with a history of
seizures
Prescribing pearls: duloxetine (Cymbalta) Correct Answer
effective for atypical pain at higher doses; appropriate for clients
who present with somatic symptoms of depression; effective for
atypical pain, such as fibromyalgia and diabetic neuropathy
Prescribing pearls: venlafaxine (Effexor) Correct Answer treats
both depression and anxiety disorders, ensure trial of higher dose
before switching to a different medication
considered when selecting a medication: Correct Answer -Client
preference
-Prior treatment response
-Anticipated adverse effects
-Comorbidities
-Half-life and interactions
-Cost
if a medication is not achieving efficacy: Correct Answer -
Increase dose gradually
-Switch to a different drug within the same class
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