Exam (elaborations)
PHM 450 Homework Questions With Complete Solutions
- Course
- PHM 450
- Institution
- Florida State University
PHM 450 Homework Questions With Complete Solutions
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PHM 450 Homework Questions With Complete SolutionsA chemical carcinogen that requires metabolic activation to
become carcinogenic is known as a(n):
A) initiator
B) electrophile
C) procarcinogen
D) genotoxic carcinogen Correct Answers C
A highly lipophilic toxicant would be expected to be stored in:
A) The lungs
B) The liver
C) Adipose tissue
D) Skeletal muscle Correct Answers C
A particle with a diameter of 1 micron or smaller will be
deposited in which part of the lung?
A) Nose
B) Trachea
C) Bronchi
D) Bronchiole
E) Alveoli Correct Answers E
A sustained elevation of intracellular ____________ is usually
an initiating step in cell death.
A) Magnesium
B) Potassium
C) Sodium
D) Calcium Correct Answers D
,A toxic substance produced by a biological organism is
generally known as:
A) poison
B) toxicant
C) toxin
D) venom
E) none of the above Correct Answers C
Acetaminophen is metabolized by the following Phase I
enzyme:
A) Glucuronyl transferase
B) CYP2E1
C) CYP3A4
D) None of the above Correct Answers B
Ammonia (pH 11) would be expected to be concentrated and
excreted in breast milk. True or False Correct Answers True
An event that results in a carcinogen-induced mutation is known
as:
A) progression
B) promotion
C) initiation
D) metastasis Correct Answers C
At low doses 2,3,7,8 tetrachlorodibenzo(p)dioxin (dioxin) has
been postulated to inhibit certain types of estrogen-dependent
cancers. This is an example of:
A) potentiation
B) dispositional antagonism
C) hormesis
, D) chronic toxicity
E) none of the above Correct Answers C
Benzene targets the bone marrow, resulting in:
A) Aplastic anemia
B) Hemolysis
C) Type II hypersensitivity
D) Arthus reactions Correct Answers A
Biotransformation always results in a chemical being less toxic
than the original chemical. True or false Correct Answers False
Botulinum toxin acts by:
A) Blocking release of acetylcholine
B) Preventing reuptake of acetylcholine
C) Mimicking acetylcholine
D) Inhibiting acetylcholinesterase Correct Answers A
Calcein and trypan blue are used in viability assays as a measure
of:
A) Cell membrane integrity
B) DNA damage
C) Cell proliferation
D) Mitochondrial function Correct Answers A
Carbon tetrachloride causes secondary damage to:
A) Mitochondria
B) Cell membrane
C) Endoplasmic reticulum
D) Cytoskeleton Correct Answers C
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