Cell-cell interactions rely on a _________ ________ to maintain contact for long periods of time. - --
binding affinity
Extended contact facilitates ______ _____________ and exchange of ___________. - --signal
transduction, cytokines
, Cytoskeletal reorganization - --may occur upon extended binding
Immune receptors have... - --immunoglobin domains
Immune receptors can be __________, __________ or __________. - --transmembrane, cytosolic or
secreted.
B cell receptor (BCR) - --contains an antibody of defined specificity
T cel receptor (TCR) - --specificity is for peptides derived from APC's degraded antigen presented on
MHC molecules.
CD4 and CD8 are T cell ________________ that define different subsets of _____ _______. - --co-
receptors, Tcell function
Recombination is directed by a _________ __________ . - --signal sequence
Dissociation constant refers to: - --measure of strength of ligand binding to a receptor
Avidity refers to: - --combined strength of binding of multiple receptors
Ligand-receptor binding induces which molecular changes in the receptor:
A)Conformational changes
B)Dimerization/clustering
C)Location in the membrane
D)Covalent modification
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