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MICR 3230 immunology final exam key questions and answers to consider University of Guelph $11.99   Add to cart

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MICR 3230 immunology final exam key questions and answers to consider University of Guelph

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  • Course
  • MICR 3230 immunology
  • Institution
  • MICR 3230 Immunology

MICR 3230 immunology final exam key questions and answers to consider University of Guelph

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  • August 23, 2024
  • 31
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • MICR 3230 immunology
  • MICR 3230 immunology
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MICR 3230 immunology final exam key
questions and answers to consider University
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, MICR 3230 immunology final exam key questions and answers to consider University of Guelph



Receptor-ligand binding occurs via multiple ___________ bonds. - --noncovalent



Each individual bond may be weak but in total they deliver a strong _______ _________. - --binding
avidity



_________________ (___) is a measure of strength of ligand binding. - --Dissociation Constant (Kd)



What are examples of bonds& interactions that can occur between a receptor and ligand? - ---
Hydrogen bonds

- Ionic bonds

- Van der Waals interactions

- hydrophobic interactions



Receptor-ligand interactions may be _______________. - --multivalent



What does multivalent mean? - --having more than one binding site for an antibody or antigen



Multivalency increases ________ of interactions. - --avidity



Individual interactions have an _________ (the strength of an individual bond). - --affinity



Affinity - --the strength of an individual bond



Avidity - --the strength of multiple bonds combined

,An interaction can have a weak _______ but overall strong _______. - --affinity, avidity



Univalent Interaction - --- single receptors bind to single ligands



Multivalent Interaction - --- multiple receptors bind to multiple ligands



Ligand-receptor binding induces ___________ ________ in the receptor. - --molcular change



What types of molecular changes can ligand-receptor binding induce in the receptor? - ---
conformational

- dimerization/clustering

- location in membrane

- covalent modification



Receptor alterations induce cascades of _____________ events. - --intracellular



What cascades do receptor alterations trigger? - --- activation of enzymes

- changes in intracellular location of molecules



Aggregation (due to ligand binding) ____________ ligand binding Kd. - --enhances



Cell-cell interactions rely on a _________ ________ to maintain contact for long periods of time. - --
binding affinity



Extended contact facilitates ______ _____________ and exchange of ___________. - --signal
transduction, cytokines

, Cytoskeletal reorganization - --may occur upon extended binding



Immune receptors have... - --immunoglobin domains



Immune receptors can be __________, __________ or __________. - --transmembrane, cytosolic or
secreted.



B cell receptor (BCR) - --contains an antibody of defined specificity



T cel receptor (TCR) - --specificity is for peptides derived from APC's degraded antigen presented on
MHC molecules.



CD4 and CD8 are T cell ________________ that define different subsets of _____ _______. - --co-
receptors, Tcell function



Recombination is directed by a _________ __________ . - --signal sequence



Dissociation constant refers to: - --measure of strength of ligand binding to a receptor



Avidity refers to: - --combined strength of binding of multiple receptors



Ligand-receptor binding induces which molecular changes in the receptor:

A)Conformational changes

B)Dimerization/clustering

C)Location in the membrane

D)Covalent modification

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