Exam (elaborations)
MICR 3230 immunology Final Exam tips new update University of Guelph
- Course
- Institution
MICR 3230 immunology Final Exam tips new update University of Guelph
[Show more]
Content preview
MICR 3230 immunology Final Examtips new update University of Guelph
,MICR 3230 immunology Final Exam tips new update University of Guelph
T & B cells use what to recognize an antigen?
Surface molecules
B cell receptors can recognize:
A whole antigen
T cell receptors can recognize:
Antigen fragments that are displayed on the surface of other cells
Antigen fragments are held within:
The binding groove of a cell surface protein called the MHC molecule
MHCs act as:
Cell surface vessel for holding & displaying fragments of antigen so T cells can engage with this
molecular complex via their TCRs
There are ______ for most MHC genes:
Many alleles
Specific MHC allele inheritance plays a role in determining an individual's susceptibility to disease
What are the 2 main types of MHC molecules?
MHC Class I
MHC Class II
MHC class I:
Classification of self
Present on all nucleated cells in the body (except RBCs)
Specialize in presenting antigen that originates from the cytosol
Ass. with T cytotoxic cell
MHC class II:
Present mostly on APCs (macrophages, B cells, DCs)
Specialize in presenting antigen from extracellular spaces that have been engulfed by APCs
,Ass. with T helper cell
Mice VERSUS humans:
H-2 complex VERSUS HLA complex
RR =
(frequency of allele+/allele- in diseased population) /
(frequency of allele+/allele- in general population)
RR = 1 means:
No effect
MHC class I -
Is present on:
All nucleated cells except for RBCs
MHC class I -
Has how many chains?
2 chains
Alpha + beta 2 microglobulin (alpha, alpha, & beta)
MHC class I -
Info about the chains:
Alpha chain coded on chromosome 6
Beta chain coded on chromosome 15
Beta 2 microglobulin acts as stabilizer
Alpha & alpha form cleft region that binds 8-10 AA long peptide fragment from an antigen
Beta sheet forms the floor of the cleft
2 alpha helices form the walls
MHC class I -
Alpha vs. beta chain encoding:
Only alpha chain encoded in the MHC, beta joins separately
, MHC class I -
Presents peptide to:
CD8+ T cells (T cytotoxic)
MHC class I -
Responsible for:
Graft rejection & clearance of ENDOGENOUS antigens (tumour, pathogen infected cells, virus infected
cells)
MHC class I -
What helps to anchor the peptide in the groove?
Some AAs
Other AAs interact with TCR
MHC class II -
Is present on:
APCs (B cells, macrophages, DCs)
MHC class II -
Responsible for:
Graft rejection & clearance of EXOGENOUS antigens
MHC class II -
Derived from:
Self or foreign exogenous extracellular processed antigens
MHC class II -
Presents antigen peptides to:
CD4+ cells (T helper)
MHC class II -
Peptide binding cleft formed by:
Pairing of the alpha 1 & beta 1 domains
Exhibit anchor AA residues that lock them into the groove & extend within the 13 core AAs
Extends other AA residues from groove to interact with TCR
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller smartzone. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $12.49. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
76658 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now