Bleeding associated with platelet disorders reflects:
✓ ~: decrease in platelet number because of:
1. decreased production (bone marrow dysfunction)
2. increased destruction (thrombocytopenia)
3. impaired function of platelets (thrombocytopathia)
Spontaneous bleeding from platelet disorders often involve
✓ ~: small vessels of mucus membranes and skin:
mucus membranes of nose, mouth, GI tract, and uterine cavity
petechiae is seen exclusively with
✓ ~: conditions of platelet deficiency
**not platelet dysfunction
thrombocytopenia
✓ ~: Platelet < 150,000
can result from:
, <<<<< Elscores <<<<<>>>>> 19/08/2024 20:17>>>>>
1. decrease in platelet production
2. increased sequestration of platelets in spleen
3. decreased platelet survival
Four primary causes of anemia
✓ ~: 1. excessive loss of RBC from bleeding
2. destruction (hemolysis) of RBC
3. Defective RBC production
4. Inadequate RBC production because of bone marrow failure
characteristics of RBC in iron deficiency anemia
✓ ~: microcytic and hypochromic
characteristics of RBC in megablastic anemai
✓ ~: macrocytic and misshaped
characteristics of RBC in sickle cell disease
✓ ~: abnormally shaped
blood loss anemia is characterized by
✓ ~: loss of iron containing blood cells in body
, <<<<< Elscores <<<<<>>>>> 19/08/2024 20:17>>>>>
hemolytic anemia is characterized by
✓ ~: destruction of RBC in the body with iron being retained
Reason for iron deficiency anemia (IDA) in adults
✓ ~: inadequate iron available for recycling:
-men/postmenopausal women: GI bleed from peptic ulcer, vascular lesions, intestinal polyps,
hemorrhoids, or cancer
-women childbearing age: menstruation
-pregnant women: fetal development increases iron requirements for erythropoiesis
Reason for IDA in children
✓ ~: blood volume increases with greater need for iron (proportionally higher in infancy
between 3-24 months):
low iron levels at birth because of maternal deficiency and a diet consisting mainly of cow's
milk (low in absorbable iron)
Clinical Course of Infectious Mononucleosis
✓ ~: -onset is insidious
-incubation period (from exposure to the development of symptoms) 4-6 weeks
-prodromal period (early stage/symptom presentation) lasts for several days and characterized
by malaise, anorexia, and chills--> precedes onset of fever, pharyngitis, and
lymphadenopathy
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