How does heparin prevent clotting? - Inactivation of Factor X (which converts prothrombin-thrombin)
Heparin drug classification - Anticoagulant
Name two reasons to administer heparin - 1. Prevent clot extension in DVT/PE
2. Prophylactically when ^ risk of thrombus formation
Why MUST heparin be administered parententerally ? - It is destroyed by the GI and therefore cannot be
administered orally
What is an appropriate INR range? - 0.8-1.2
Full therapeutic effect is measured by: - Blood tests
How long are patients on IV Heparin. - It depends on two things:
1. Risk of thrombus formation of the med is stopped
Low risk= reversible factor like surgery
High risk= unknown/persistent factor
2. Risk of bleeding if the med is continued
Contraindications of Heparin: - Thrombocytopenia, bleeding disorders, active bleeding other than DIC,
sensitivity to beef/pork
Most common adverse effect - Bleeding
If tx lasts longer than 6 months - risk of: - Osteoporosis
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