"Loss of function in the KCNQ1-encoded IKs potassium channel?" - Long QT Syndrome/LQTS.
What voltage-gated channel is caused by Congenital LQTS? - Voltage-gated potassium channels.
What is the MEDICATION used to tx Brugada? - Quinidine.
Primary Prevention ICD in LQTS? - 1. QTS > 550 ms and not LQT1
2. LQT2 women, QTc > 500 ms +/- Sx
3. Infants with 2:1 AV block?
4. JLNS (LQTS with deafness)?
Is an ICD always indicated in LQTS? - No.
When is an ICD indicated in LQTS? - Aborted cardiac arrest.
Rx intolerance or breakthrough.
Screening in LQTS? - Mutation-specific gene testing is recommended for family members and other
appropriate relatives subsequently following identification of LQTS-causative mutation in an index case.
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