Exam (elaborations)
FTM1 drugs exam 1 SGU/SGU SOM FTM 2: Test 2 Diseases study guide
- Course
- Institution
FTM1 drugs exam 1 SGU/SGU SOM FTM 2: Test 2 Diseases study guide
[Show more]
Content preview
FTM1 drugs exam 1 SGU/SGU SOM FTM 2:Test 2 Diseases study guide
Taxol - ANS Anti-cancer drug, Prevent microtubule disassembly
Colchicine - ANS anti-cancer and anti-gout, Prevent microtubule assembly (polymerization)
Fights inflammation
Phalloidin - ANS Disrupt actin function so no cell movement, Inhibit RNA poll II not
absorbed by GI tract not toxic by oral intake
Ciproflaxin - ANS antibiotic, inhibit dna gyrase
novabiocin - ANS antibiotic, inhibit dna gyrase
AZT or zidovudine - ANS Disrupt DNA elongation base lacks 3'OH
Acyclovir - ANS Disrupt DNA elongation base lacks 3'OH
Tenofovir - ANS Disrupt DNA elongation Competes w/ dATP
Didanosine (ddI) - ANS Disrupt DNA elongation base lacks 3'OH
Adenine Arabinoside
(AraA) - ANS 3'OH = stereo restraint chain termination
Cytosine Arabinoside (araC) - ANS anti-cancer, 3'OH = stereo restraint chain termination
Camptothecin - ANS Binds and inhibits topoisomerase I
Etoposide - ANS inhibits topoisomerase II
Actinomycin D - ANS Inhibit RNA pol BOTH prokaryotes + eukaryotes
Rifampin - ANS Inhibit RNA pol inhibit initiation of transcription
⍺-Amanitin
, (mushroom!) - ANS Inhibit RNA pol II hepatotoxicity death
Streptomycin - ANS Blocks initiation: prevents assembly of ribosome by binding to 30s
Tetracycline - ANS Blocks elongation: prevents aminoacyl-tRNA access to A site
Erythromycin - ANS Blocks elongation: blocks ribosome translocation by binding to 50S
Chloramphenicol - ANS Blocks elongation: prevents peptidyl transferase activity in
prokaryotes
Cycloheximide - ANS Blocks elongation: prevents peptidyl transferase activity in eukaryotes
puromycin - ANS Blocks elongation: premature termination in translation by bearing
structural
resemblance to aminoacyl-tRNA
Diphtheria toxin - ANS Inactivates EF-2 prevent translocation (translation??)
Allopurinol - ANS xanthine oxidase inhibitor
Sulfonamide (sulfa drugs) - ANS Inhibit folate synthesis
I Cell disease - ANS -lysosomal storage disorder
-lysosomes lack their normal complement of several enzymes
-many different molecules are not degraded and accumulate forming inclusion bodies
-grouped as mucolipidosis Type II
-transport into lysosomes is defective, lack of phosphorylase to form the mannose 6-P marker,
n-glycosylation itself is normal
Adherence of E. coli - ANS -E. coli attaches to mannose residues that incorporated in the
plasma membrane of human cheek cells
-first step in bacterial infection
Adherence of Helicobacter pylori - ANS -helicobacter pylori attached to the gastric surface
-bacterium leads to ulcers by interaction with a specific blood group antigen of the gastric
epithelium
Hypoxia - ANS -reduction in normal level of oxygen tension
-occurs during several pathophysiological processes including tumorigenesis
-HIF-1 activity (HIF1alpha and HIF1beta)
Osteogenesis Imperfecta - ANS -brittle bones
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller excellentrevision964. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $7.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
80364 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now