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Regis College - PSYCH 643 > Study Guides Psychopharmacology (Latest 2019) Rated A+
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Regis College - PSYCH 643 > Study Guides Psychopharmacology (Latest 2019) Rated A+
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Haloperidol [Haldol], Chlorpromazine [Thorazine], Prochlorperazine [Compazine],Typical Antipsychotic Rx
Fluphenazine [Prolixin]
Risperidone [Risperdal]
Olanzapine [Zyprexa]
Quetiapine [Seroquel]
Atypical Antipsychotic Rx
Clozapine [Clozaril]
Ziprasidone [Geodon]
Aripiprazole [Abilify]
1. Psychotic disorders
2. Acute agitation - haloperidol, ziprasidone
What are the indications for antipsychotic
3. Mood disorders - MDD, BP2 - adjunct to SSRI, esp. Aripiprazole
therapy?
4. Movement d/o involving excessive dopaminergic stimulation (i.e. Huntington's,
Tourette's)
Which antipsychotic is associated with Clozapine [Clozaril]
agranulocytosis?
Which antipsychotic is associated with Ziprasidone [Geodon]
prolongation of QT interval?
Which antipsychotic is the least sedating? Risperidone [Risperdal]
What are the AE associated with 1. Extrapyramidal sx - TD, NMS, akathisia (typicals!)
dopaminergic blockade in patients on 2. Galactorrhea, gynecomastia, amenorrhea 2' to elevated prolactin
antipsychotics?
1. Acute Dystonia - onset w/in hrs to days of tx; sx - torticollis, oculogyric crisis, muscle
spasms; tx - benztropine, benadryl
What are the extrapyramidal sx associated
2. Akathisia - comes on most after tx; sx - restlessness, tremor; tx - monitor dose,
with antipsychotic use and how are they
change to atypicals
managed?
3. TD - irreversible; sx - chorea, involuntary movements (face, jaw); tx - switch to
atypicals
Neuroleptic Malignant Syndrome (NMS)
Sx - hyperthermia, muscle rigidity, cramps, tremor, severe HTN or hypotenions,
What medical emergency is associated with
tachycardia, delirium, seizures, agitation
antipsychotic use?
Dx - high suspicion on any pt taking antipsychotics, elevated CPK and WBCs
Tx - d/c tx, start IV Dantrolene
Fluoxetine (Prozac), Escitalopram [Lexapro], Citalopram [Celexa], Fluvoxamine [Luvox],
SSRIs
Paroxetine [Paxil], Sertraline [Zoloft]
1. Depression (1st line)
What are the indications for SSRIs? 2. Long term management of anxiety disorders
3. Bulimia nervosa
1. Sexual dysfunction
2. GI effects - decrease appetite, diarrhea
What are the common AE of SSRIs?
3. Serotonin Syndrome (interactions w/ MAOIs, other SSRIs)
4. Withdrawal
What is the MOA of TCAs? Block NE and serotonin transporter site
TCAs Imipramine, amitryptiline, doxepin, clomipramine, nortriptyline
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