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Immunology and Serology - Complement system questions with correct answers 2024/2025
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Immunology and Serology - Complement system questions with correct answers 2024/2025
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Immunology and Serology -Complement system
Complement proteins - ANSset of proteins that play a role in cytolytic destruction of cellular
antigens and specific antibody
C1 and Factor D - ANSMost plasma proteins are synthesized in the liver except:
C1 - ANSproduced in the intestinal tissue
Factor D - ANSproduced by adipose tissue
Chemotaxins - ANSability of WBC to migrate at the site of infection
C5a, C5b, C6, C7 - ANScomplement factor involved in Chemotaxin
C3b - ANSComplement factor for immune adherence
C2b - ANSComplement factor that is a kinin activator
C1, C4b - ANSComplement factor for virus neutralization
Anaphylatoxins - ANSfound at muscle to release histamine
C3a, C4a, C5a - ANSWhat complement factor or factors are associated with • Anaphylaxis?
C5a - ANSMost potent anaphylatoxin
Opsonins - ANSuse to prepare for phagocytosis
C3b, C4b, C5b - ANSComplement factors found in opsonins
C3b - ANSbest opsonin factor
classical pathway - ANSmost common pathway
contains all the compliment proteins from C1-C9
IgG and IgM - ANSCP is initiated by:
, C1q, C1r, C1s - ANSRecognition unit of CP:
C4b, C2a, C3b - ANSactivation unit of CP:
C5-C9 - ANSMAC for the three major pathways of activation
Immune complex - ANSActivating substance of CP:
C4b2a - ANSC3 convertase of classical pathway
C4b2a3b - ANSC5 convertase of classical pathway
Ca++ - ANShold C1q,C1r and C1s together
Cell lysis - ANSend product of the 3 pathways
Alternative pathway - ANSbypass pathway
lacks C1, C2 and C4
LPS of bacterial cell wall - ANSactivating substance of AP:
water and plasma - ANSactivates alternative pathway
Alternative pathway - ANStriggered by bacteria,fungal cell wall, virus, virally intended cell, tumor
cells, parasites
Aggregates of IgG, IgG4,yeast cell wall or zymosan,LPS,CVF
C3, Factor B, Factor D - ANSrecognition unit of AP:
Factor B - ANSBinds to C3b to form C3 convertase
Factor D - ANScleaves factor B
C3bBb - ANSC3 convertase of the alternative pathway
C3bBbP - ANSC5 convertase of the alternative pathway
Mg++ - ANSion that holds C3, factor d and factor B to produce C3 convertase
lectin pathway - ANSC1 not needed
Mannose group on microbial cells - ANSActivating substance of LP
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