Conventional and High Sensitivity CRP
C-reactive Protein (CRP) correct answers Acute-phase protein:
1. Released in inflammation & tissue damage
2. Disappears when inflammation subsides
3. Lacks disease specificity
4. Elevated in many disorders:
-Bacterial and viral infections
-Rheumatic fever
-Malignant diseases
-Rheumatoid arthritis
-Tuberculosis
-Post-op
-Myocardial infarction
5. Appears rapidly after acute tissue injury (4-6 hours)
6. Concentration can rise to 1k times normale
7. Heat labile: destroyed at 70 degrees Celsius for 30 minutes
8. Synthesized in the liver
9. Opsonization :
-Binds to C-polysaccharide in bacterial cell walls
- Complement activation
- Innate immunity
-Binding is calcium-dependent
High Sensitivity CRP (hs-CRP) correct answers 1. Used to assess risk for acute
coronary syndrome
2. Stimulated by IL-6 during inflammation
3. Increases are minimal
4. Often less than reference range for conventional CRP
5. Increased baseline indicates higher risk of CAD and/or death in individuals with or
without clinical symptoms
6. Treatments to decrease inflammation reduce risk of cardiovascular disease
Clinical significance of C-reactive Protein (CRP) correct answers 1. Monitoring
inflammation
2. Evaluation treatment
3. An important risk marker for cardiovascular disease in addition to being a prototypical
marker of underlying inflammation. Patients with high CRP concentrations are more
likely to develop stroke, myocardial infarction, and significant peripheral vascular
disease
Clinical significance of High Sensitivity CRP (hs-CRP) correct answers Evaluate your
risk of developing coronary artery disease, a condition in which the arteries of your heart
are narrowed.
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