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PHM 312: Pharmaceutics II (Final) (Complexation) Questions With Complete Solutions
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PHM 312: Pharmaceutics II (Final) (Complexation) Questions With Complete Solutions
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PHM 312: Pharmaceutics II (Final) (Complexation)Questions With Complete Solutions
________________ is an important metal ion that is present in
many protein conferring _______________ and
____________________ Correct Answers Zinc; Structure;
Stability
Can a drug with a higher affinity displace another drug from the
same binding site? Why? Correct Answers Yes, because
affinity binding is reversible
Complexation can also aid in the
______________________________ (Ex: ion-exchange resins)
and can affect the ____________________________ in the
body by altering its propensity to
_______________________________ Correct Answers
optimization of delivery systems; distribution of the drug;
protein binding to albumin
Complexation of drugs with some hydrophilic compounds can
actually _________________________ of these drugs and
thereby _____________________ the extent and duration of
these drug's activities Correct Answers Enhance the excretion;
decreasing
Depending on the type of interaction involved in complexations,
ligand-substrate interactions are classified as either
____________________ or _______________________
Correct Answers Coordination complexes; Molecular
complexes
, Does Complexation always result in increased solubility and
absorption of drug? Provide an example Correct Answers No,
In some instances, complexation is not beneficial and can lead to
decreasing the solubility of drugs and decrease absorption of
drugs into the body
Ex: Aqueous solubility of tetracycline HCl decreases
significantly when it forms a complex with calcium ions during
co-administration with some drugs like antacids or foods high in
calcium ions
How many residues of D-Glucose do Alpha, Beta, and Gamma
cyclodextrins have respectively? Correct Answers Alpha = 6
residues of D-Glucose
Beta = 7 residues of D-Glucose
Gamma = 8 residues of D-Glucose
Human plasma is composed of about
____________________________ Correct Answers 200
known proteins
If a drug is bound to adipose tissue, what type of volume of
distribution is it said to have? Correct Answers Relatively low
volume of distribution
If counter ions are present in a coordination complex, what type
of complex will be formed? Correct Answers An electrically
neutral complex
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