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PHM 350 Exam 1 | 450 Questions | With Complete Solutions
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PHM 350 Exam 1 | 450 Questions | With Complete Solutions
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PHM 350 Exam 1 | 450 Questions | With Complete Solutions(skeletal muscle) neuromuscular junctions Correct Answers all
the junctions between somatic motor neurons and skeletal
muscle
[A-] Correct Answers concentration of ionized (non-
protonated) acid
[B] Correct Answers concentration of non-ionized (non-
protonated) base
[BH+] Correct Answers concentration of ionized (protonated)
base
[HA] Correct Answers concentration of non-ionized
(protonated) acid
2 types of cholinergic receptors Correct Answers muscarinic
nicotinic
3 outputs from the spinal cord Correct Answers ANS - SNS
ANS - PNS
Somatic
5 drug movement mechanisms Correct Answers bulk flow
transporter
,endocytosis
exocytosis
diffusion
a drug does not have a single effect because Correct Answers a
drug interacts with multiple types of receptor
a drug interacts with a single type of receptor located on
different cell types coupled to multiple response mechanisms
a drug with a high TI and SSM may have Correct Answers
high or low therapeutic potency
a drug with high therapeutic potency may have high or low
Correct Answers TI and SSM
a drug with low therapeutic potency may have a Correct
Answers high or low TI and SSM
a drug with low TI and SSM may have Correct Answers high
or low therapeutic potency
a measure of drug safety (TI) can measure the Correct Answers
ED50
a non-ionized drug will diffuse across the membranes into the
other chamber until Correct Answers equilibrium
,absorption Correct Answers important processes from getting a
drug from any space or compartment in the body to any other
space
acetylcholine activates __________ receptors Correct Answers
N and M cholinergic receptors
acetylcholine has the same affinity for Correct Answers
nicotinic and muscarinic receptors
acetylcholine is a Correct Answers choline ester so it is
possible that we could change it a little bit to enhance its ability
to be absorbed and to enhance the possibility that it will not be
metabolized so quickly so it would stay in the blood for a
sufficient time and have effects
acetylcholine is a _______ molecule Correct Answers charged
(if you put it in the gut it doesn't get into the blood very fast)
not absorbed through the GI tract or mucosa
does not enter the CNS
acetylcholine is metabolized by Correct Answers
acetylcholinesterase at all cholinergic synapses (this enzyme is
very fast at this but not good at metabolizing any other choline
ester)
acetylcholine is metabolized by nonspecific cholinesterase in the
Correct Answers plasma (without it you get acetylcholine
staying in the synapse)
, acetylcholine is not absorbed across Correct Answers mucosa
or GI tract
does not enter the central nervous system
acetylcholine is present anywhere there is a Correct Answers
cholinergic synapse
ACh degradation causes the production of Correct Answers
choline
ACh esterase Correct Answers enzyme that metabolizes ACh
ACh is a substrate for Correct Answers AChEase and ChEases
ACh is equally good for both
it terminates ACh action at cholinergic synapses
other choline esters are also substrates for ChEases but not
AChEase
ACh is proven to be an Correct Answers agonist
ACh is very rapidly metabolized by Correct Answers
ACHEase and ChEases in plasma
adjunct to ECT Correct Answers help with the symptoms of
electroconvulsive shock treatment
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