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CMB2004 PRACTICE EXAM
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CMB2004 PRACTICE EXAM 2024-2025Bone marrow - ANSWER Origin of haematopoietic stem cells?
Bone Marrow - ANSWER Site of B cell development to the stage of immature B
cell?
kappa - ANSWER what light chain is expressed first?
negative selection - ANSWER If BCR expressed by immature B cell binds to a
self-cell surface antigen, the B cell is removed via?
PAX5 - ANSWER TF that haematopoietic cells express leading to B cell
development
plasma/memory cells - ANSWER Activated B cells in the periphery can develop
into?
Heavy chain - ANSWER Which Ig chain is re-arranged first
produced by vpreB and gamma 5 to bind to H chain and make sure it works -
ANSWER What is the surrogate light chain
heavy= V/D/J, Light = V/J = Kappa/Lambda - ANSWER Which gene segments get
re-arranged in the heavy/light chains?
Activation of B cells to produce plasma cells - ANSWER Which stage of B cell
development sees the most cell division
Gene recombination, for Heavy/light chain rearrangement - ANSWER what do the
RAG 1 and 2 genes do and when
cell loss (once gamma loci has been tried) - ANSWER what is the fate of a pre-B
cell with non-productive rearrangements of the light chain genes
clonal deletion/receptor editing - ANSWER If the BCR expressed on an immune B
cell binds multivalent self antigen, what are the 2 possible outcomes?
thymus - ANSWER origin of thymocytes?
, negative selection based on too high affinity - ANSWER process of elimination of
self-reactive T cells
cortex (rearrangement genes), and medulla (post positive selection) of thymus -
ANSWER site of T cell development and body location?
V-J/D-J - ANSWER Gene segments for alpha/beta chains that get rearranged first?
lymphoid/epithelial cells/macrophages/dendritic cells - ANSWER cells other than
thymocytes present in the thymus are?
beta - ANSWER alpha or beta genes rearranged first
Rearranged beta chain plus invarient pre-T alpha - ANSWER What is the pre-TCR
CD3 transmits signal to T cell nucleus following TCR recognition of MHC -
ANSWER What does the CD3 molecule do and why is it important?
No - ANSWER Do gamma, delta T cells normally express CD4/8
positive selection ensures T cells can recognise MHC, negative ensures that they
don't bind too well to MHC (self reactive) - ANSWER What is positive and
negative selection of T cells
CD8+ - ANSWER If a T cell recognises peptide and MHC 1 what marker does it
have on it's surface?
No, Positive is to remove T cells that don't bind MHC, negative removes T cells
that bind MHC too strongly - ANSWER Are the criteria for positive and negative
selection of immature T cells the same?
CD45/CD19 - ANSWER what markers are specific for B cells
M - ANSWER What is isotype of pre B cell
Pre-B cell - ANSWER Cells with only H genes rearranged, and surrogate Light
chain with M constant
Ig alpha/beta - ANSWER what couples pre-B cell receptors?
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