Process by which a drug enters the circulatory system
Absorption
(blood).
Intravenous (IV) & Intra- Administration/Dosage routs that do not require
Arterial absorption.
Absorption, Distribution, ADME
Metabolism, & Elimination...
The Pharmacokinetic
Process
Dependence characterized by a perceived need to
Addiction take a drug to attain the psychological & physical
effects of mood altering substances.
Natural attraction - the strength by which a particular
Affinity
chemical messenger binds to its receptor site on a cell
Drug that mimics the action of a neurotransmitter when
it binds to a particular receptor site - i.e. & triggers the
Agonist
cell's response in a manner similar to the action of the
body's own chemical messenger.
Substance of a usually harmless nature that produces
Allergen
an abnormal hypersensitive reaction.
A hypersensitive reaction to any usually harmless
Allergic Response
substance that does not normally cause a reaction.
Severe allergic response resulting in immediate life-
Anaphylactic Reaction threatening respiratory distress, usually followed by
vascular collapse & shock accompanied w/ hives.
Angioedema Abnormal accumulation of fluid in tissue.
Drug that neutralizes or counteracts the effects of a
Antagonist neurotransmitter or another drug when it binds to a
particular receptor site.
Foreign substance that is recognized by the immune
Antigen system & induces the immune system to produce
antibodies to defend against the foreign substance.
Degree to which a drug or other substance becomes
Bioavailability
available to the target tissue after administration.
Fortified area that prevents many substances from
entering the cerebro-spinal fluid from the blood. This
area is formed by glial cells that envelope capillaries in
Blood-Brain Barrier
the fcentral nervous system. This creates a shield that
blocks many water-soluble compounds, but is
permeable to lipid-soluble substances.
Point @ which no clinical response occurs w/
Ceiling Effect
increased dosage of a drug.
Rate @ which a drug is eliminated from a specific
Clearance
volume of blood per unit of time.
Any disease, condition, or symptom for which a drug
Contraindication
will not be beneficial & may be harmful.
State in which a person's body has adapted
Dependence physiologically & psychologically to a drug & cannot
function w/o it.
Process by which a drug moves from the blood into
Distribution other body fluids & tissues & ultimately to its site(s) of
action.
Dose Quantity of a drug administered at one time.
Use of a drug for purposes other than those
Drug Abuse prescribed &/or in amounts that were not directed. This
is often linked to addiction.
When a drug is affected in some way by another drug,
Drug Interaction foods, or other substances, such as when enzymes that
metabolize the drug are induced or inhibited.
Drug Interaction The combined effect of 2 drugs is equal to the sum of
Relationship: Addition the effects of each drug taken alone.
Drug Interaction The action of 1 drug negates the action of a 2nd drug.
Relationship: Antagonism
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