Bio/BioChem AAMC FL 1 || with Errorless Solutions 100%.
Protein Aggregation correct answers Misfolded or disordered proteins have a tendency to clump
together
Based on the data presented in the passage, which statement best describes the HSP110ΔE9
allele?
A.
Cancer-promoting and dominant to HSP110WT
B.
Cancer-promoting and recessive to HSP110WT
C.
Cancer-suppressing and dominant to HSP110WT
D.
Cancer-suppressing and recessive to HSP110WT correct answers C- Correct, this is because in
Figure 1, DeltaE9 has less tumor growth size than WT (meaning DeltaE9 is Tumor suppressing,
the second part is found in Table 2, in which with the WT (64% of the protein aggregated) and in
the DeltaE9 (96% of the Protein aggregated), and when combined (100% of the protein was
aggregated) This can conclude that since the initial DeltaE9 % Aggregation was higher than the
WT (96% vs 64%) so we can conclude that since the combo was 100%, the DeltaE9 is Dominant
over the WT.
Based on the passage, in MSI CRC primary tumor cells, the size of the deletion in the HSP110
T17 microsatellite is inversely correlated with:
A.
the amount of HSP110ΔE9 protein expressed.
B.
the number of mature HSP110WT transcripts synthesized.
C.
the frequency of the omission of HSP110 Exon 9 during splicing.
D.
the extent of premature translation termination in Exon 10. correct answers B- Correct, because
in Table 1, as the amount of deletions goes up, the amount of DeltaE9 is expressed, and this
would lead to a decrease in the amount of WT transcripts synthesized.
A-Wrong, the expression of DeltaE9 goes up with deletion
C- Wrong, this would go up too, in the passage it states "The larger HSP110 T17 deletions cause
Exon 9 to be omitted from the final sequence during pre-mRNA processing" So the larger, the
more more likely Exon 9 is to be omitted
D- Wrong, this would also go up because the more deletions the more premature stop codons
there will be that mess up the process
,A man with a CRC mutation that results in the synthesis of HSP110ΔE9 and a woman that does
not carry this mutation in any of her tissues have a child. What is the percent chance that the
child will inherit the CRC mutation?
A.
0%
B.
25%
C.
50%
D.
100% correct answers A- Correct, the passage states "People with MSI CRC have HSP110ΔE9
transcripts in cancerous tissue only." Which means, this is not a genetic thing and so theoretically
the child will not have any chance of getting it handed down to them
Which nucleotide pairing(s) would be recognized by the MMR system during DNA replication?
dTMP and dCMP
dGMP and dAMP
dAMP and dTMP
A.
I only
B.
III only
C.
I and II only
D.
I, II, and III correct answers C- Correct, as you can see, the question asks about the MMR
(Mismatch Replacement), which replaces the wrong bonds with new ones, and biologically, (T
and C) and (G and A) do not pair together and would be picked up by the repair system to be
fixed.
The information in the passage best supports the conclusion that Intron 8 of HSP110 most likely
contains which of the following?
A.
Stop codon
B.
Splice acceptor site
C.
HSP110 gene promoter
D.
Partial coding sequence of HSP110 correct answers B- Correct, because the passage states
"Researchers studying MSI in CRC cell lines and primary tumors observed that 100% of those
analyzed contained deletions of 3 to 8 base pairs in the 17-thymine nucleotide microsatellite
(T17) located in Intron 8 of the gene encoding heat shock protein 110 (HSP110)" Since there are
100% deletions in T17, then this must have something to do with splicing for processing the
mRNA
, A- Wrong, there is not a stop codon in T17
According to the information in the passage, HSP110 is most likely which type of protein?
A.
Adhesion
B.
Chaperone
C.
Clathrin
D.
Enzyme correct answers B- Correct, because the passage states that HSP110 is a heat shock
protein, which facilitates proper protein folding and inhibits the formation of nonfunctional
protein aggregates. Proteins that perform this function are chaperone proteins.
A,C- Do not make sense to me nor seem relevant
D- Wrong, the passage never states anything about catalyzing a reaction or changing a substrate
Which amino acid, in addition to tryptophan, is most likely to be transported by AT1?
A.
Phenylalanine
B.
Lysine
C.
Arginine
D.
Glutamate correct answers A- Correct, the passage states that AT1 is a neutral Amino acid
transporter, and Phenylalanine is neutral and it shares a aromatic structure like Tryptophan
Based on the information in the passage, a mature AT1 mRNA is most likely to contain a
sequence coding for which genetic factor(s)?
A.
Signal sequence
B.
Introns
C.
Promoter
D.
Nuclear localization signal correct answers A- Correct, because the passage indicates that AT1 is
a transmembrane protein. Transmembrane proteins enter the endomembrane system by docking
at the rough ER. This is facilitated by using a signal sequence.
B- Mature mRNA do not have introns
C- Mature mRNA do not have promoter sequences
