What distinguishes TCAs from SNRIs despite their similar mechanism of action?
✓ ~~~ TCAs have different adverse effects relative to SNRIs.
Name the tertiary amine that serves as the prototype drug for TCAs.
✓ ~~~ Imipramine
Which TCAs are classified as secondary amines?
✓ ~~~ Desipramine and nortriptyline.
What are the N-demethylated metabolites of imipramine and amitriptyline,
respectively?
✓ ~~~ Desipramine (of imipramine) and nortriptyline (of amitriptyline).
Name two related "tetracyclic" antidepressant agents that are commonly included in
the general class of TCAs.
, ✓ ~~~ Maprotiline and amoxapine.
What neurotransmitter reuptake do TCAs and amoxapine inhibit?
✓ ~~~ Norepinephrine and serotonin.
Besides TCAs, which specific agents are relatively selective inhibitors of
norepinephrine reuptake?
✓ ~~~ Maprotiline and desipramine.
Apart from inhibiting neurotransmitter reuptake, what other receptors do TCAs
block?
✓ ~~~ Serotonergic, α-adrenergic, histaminic, and muscarinic receptors.
What is likely responsible for many of the adverse effects of TCAs?
✓ ~~~ Actions at serotonergic, α-adrenergic, histaminic, and muscarinic receptors.
Besides serotonin receptors, what other receptors does amoxapine block?
✓ ~~~ Amoxapine also blocks 5-HT2 and dopamine D2 receptors.
What are the actions of TCA's?
✓ ~~~ TCAs improve mood, in 50% to 70% of individuals with major depression.
How long does it take for TCA's to start working?
✓ ~~~ 2 weeks or longer
Why is tapering doses recommended in TCA's?
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller MASTER01. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $9.99. You're not tied to anything after your purchase.