NURS 3380 - CNS & Neurodegenerative-Questions with Correct Answers/ Verified
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Course
NURS 3380
Institution
NURS 3380
What quality does a drug have to have in order to cross the BBB?
Lipophilic
If a drug is _______ or ________ _________, it cannot cross the BBB
Ionized, protein bound
What causes Parkinson's disease?
Neurons shrink —> decreased amount and ability to release dopamine —> abnormal signa...
Carpidopa _________ the amount of levadopa metabolized in the small intestines
Decreases
What drugs are COMT inhibitors, used to prevent the breakdown of dopamine?
- entacapone
- Tolcapone
What are the side effects of Entacapone, the prototype COMT inhibitor?
- N/V
- Diarrhea
- yellow/orange urine
What are the side effects of Tolcapone, the preffered COMT inhibitor for Parkinson’s?
- may enhance side effects of levadopa
- diminished effect
- malignant melanoma
- N/V
What is the preffered COMT inhibitor for Parkinson's disease?
Tolcapone
What drugs interact with COMT inhibitors by increasing effects (entacapone, Tolcapone)?
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