HUN4221 Quiz 1| Questions and Answers 2024
folate is the generic descriptor for ____ and related compounds exhibiting the ___ of folic acid ** Answ** folic acid; biological activity
folic acid vs food folate ** Answ** synthetic form vs natural form
supplements usually have ___ ...
three components of folic acid ** Answ** - pteridine
- PABA
- glutamic acid
two components of folic acid ** Answ** - pteroic acid (pteridine and PABA)
- glutamic acid
highest amounts of food folate ** Answ** pinto beans and lentils
food folate and folic acid ___ the same ** Answ** function
differences in food folate compared to folic acid ** Answ** - less double
bonds (more H) and can have multiple glutamic acid residues
food folate is almost exclusively in ___ form as polyglutamate derivatives of ___
** Answ** reduced; tetrahydrofolic acid
two common forms of food folate ** Answ** 5-methyl-THF and 10-formyl-
THF
, two step absorption of folate ** Answ** - hydrolysis - GCPII
- absorption (saturable and non-saturable)
enzyme that hydrolyzes folate ** Answ** glutamate carboxypeptidase II
GCPII cleaves food ___ in jejunal ___ to monoglutamate ** Answ**
polyglutamates, brush border
GCPII acts as an ___ cleaving ___ glutamates ** Answ** exopeptidase,
terminal
optimum pH for GCPII ** Answ** 6.5
saturable absorption is a ___ process ** Answ** carrier mediated process
intestinal uptake of folate is mediated by ___ ** Answ** proton-coupled folate
transporter (PCFT)
PCFT is a ___ protein located on ___ membrane of enterocyte ** Answ**
transmembrane, apical
non-saturable absorption happens ___ ** Answ** without a transporter
within intestinal cell, folic acid is reduced to ___ in 2 step process ** Answ**
tetrahydrofolate
___ is required to reduce folic acid to THF and it is easily ___ ** Answ**
dihydrofolate reductase; saturated
___ folic acid found in blood when more than ___ micrograms are taken **
Answ** oxidized, 200
folic acid loses ___ in each step of reduction to THF ** Answ** 2 hydrogens
circulating form of folate ** Answ** 5-methyl THF
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller smartchoices. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $8.99. You're not tied to anything after your purchase.
