Flapping tremor and neurologic sign, caused by nitrogenous metabolites which cannot
be detoxified by the damaged liver
Atrophy and gross depigmentation of the dopamine-producing cells of the substantia
nigra and locus coeruleus - CORRECT ANSWER: Parkinson disease
Histologically characterized by Lewy bodies which are intracytoplasmic, eosinophilic
inclusions within neurons
Atrophy of the caudate, putamen, and globus pallidus - CORRECT ANSWER:
Huntington disease
Caudate atrophy leads to "bat wing" lateral ventricles
, Autosomal dominant disorder with multiple benign hamartomatous polyps and melanin
pigmentation of the oral mucosa, hands and genitals - CORRECT ANSWER: Peutz-
Jegher Syndrome
Ball-valve obstruction by left atrial mass - CORRECT ANSWER: Myxoma
Most common primary tumor of the heart in adults
Barrett esophagus is the only recognized precursor - CORRECT ANSWER: Esophageal
adenocarcinoma
Barrett esophagus = squamous to columnar metaplasia (specialized, intestinal type
epithelium) in the distal esophagus
Biliary tract disease commonly seen in association with ulcerative colitis - CORRECT
ANSWER: Primary sclerosing cholangitis
Histologically characterized by onion-skin fibrosis of bile ducts
Black-blue papule with irregular borders - CORRECT ANSWER: Malignant Melanoma
Depth of invasion correlates with prognosis
Bleeding with passage of grape-like structures, increased hCG, and rapid increase in
uterine size - CORRECT ANSWER: Hydatidiform mole
Similar presentation without uterine enlargement = choriocarcinoma
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