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Myasthenia Gravis (Pauly - 14 points) – Questions And Verified Answers
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Myasthenia Gravis (Pauly - 14 points) – Questions And Verified Answers
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Myasthenia Gravis (Pauly - 14 points) – Questions AndVerified Answers
Myasthenia Gravis Right Ans - grave muscular weakness
Chronic autoimmune Right Ans - neuromuscular (junction) disorder
History of Right Ans - fatiguable weakness & recovery with rest
Rare, affects Right Ans - all people regardless of age, race, ethnicity, family
history
since autoimmune, is genetic predisposition but MG not directly hereditary
Variable weakness in skeletal muscle Right Ans - ocular, bulbar, limb, and
respiratory
Selective vulnerability Right Ans - muscle weakness in eyes, eyelids,
shoulder, hip, diaphragm, neck, chewing/swallowing muscles
Muscle weakness results in Right Ans - double vision, obstruction of vision,
trouble chewing/swallowing, talking, breathing, and dysfunction of arms/legs
Generalized disease Right Ans - weakness affects ocular muscles and
variable combo of bulbar, limb, and respiratory
Most severe type of MG Right Ans - generalized: due to involvement of
respiratory muscles
Ocular myasthenia Right Ans - weakness limited to eyelids/extraocular
muscles
Neonatal MG Right Ans - transient form - mother has MG and passes
antibodies to baby
breast feeding can transfer antibodies
usually subsides once antibody transmission stopped (birth)
, Congenital MG Right Ans - non-autoimmune related, caused by an issue
than occurred during development
Ptosis Right Ans - drooping of one or both eyelids
Diplopia Right Ans - double vision
Bulbar Right Ans - face and throat muscles
- difficulty chewing, limited facial expressions
Dysarthria Right Ans - altered speaking
Dysphagia Right Ans - difficulty swallowing
Neck and limb muscles Right Ans - weakness in arms, fingers, legs
Myasthenic Crisis Right Ans - weakness in chest muscles
most serious, affects respiratory
Symptoms Right Ans - worsen throughout the day and improve with rest
Early symptoms are transient Right Ans - take weeks-months to progress
Symptoms peak Right Ans - ~2 years (active stage)
Diagnosis Right Ans - Ice pack test
Tension test
Serological tests
Repetitive nerve stimulation
Thymus imaging
Ice pack test Right Ans - one of main diagnosis tests
2-5 mins with ice pack on eye (only ptosis)
*cooling improves neuromuscular transmission
Tension test (edrophonium) Right Ans - increase in muscle strength
NO LONGER USED due to false positives
-short 1/2 life AChEi IV
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