tumors with what have better responses to and better survival after PD-(L)1 therapy? -
Answer-tumors with IFN-gamma gene profile
high level of infiltrative CD8+ T cells
true / false
tumors with mismatch repair mutations have a high mutation burden and thus are very
sensitive to anti-PD-(L)1 therapy - Answer-true
what are the blood biomarkers of poor prognosis? - Answer-high LDH
high CD25
high neutrophil: lymphocyte
true / false
nivolumab is an anti-PD-1 that is used as an adjuvant therapy for stage III melanoma
after surgical excision - Answer-true
tumor targeted therapies improve which one;
a. progression free survival
b. overall survival - Answer-a. progression free survival
, immune checkpoint inhibitor therapies improve which one;
a. progression free survival
b. overall survival - Answer-b. overall survival
when do side effects due to immune checkpoint inhibitors commonly arise? - Answer-
weeks - months later after starting
the timeline of immune related side effects mirror what? - Answer-evolution of body's
immune response to activate T cells
side effects are due what? - Answer-autoimmunity
skin symptoms are more common with anti-CTLA-4 / anti-PD-(L)1 / both? - Answer-both
GI symptoms are more common with anti-CTLA-4 / anti-PD-(L)1 / both? - Answer-anti-
CTLA-4
lung symptoms & thyroid dysfunction are more common with anti-CTLA-4 / anti-PD-(L)1
/ both? - Answer-anti-PD-(L)1
what should be used if there are severe / persistent side effects? - Answer-oral / iv CS
true / false
use of oral / iv CS does NOT negatively affect how cancer will respond to
immunotherapy - Answer-true
what are all anti-CTLA-4 and PD-1 inhibitors? - Answer-monoclonal antibodies
all anti-CTLA-4 and PD-1 inhibitors are given how? - Answer-injection / iv infusion
how can immunotherapy lead to autoimmunity? - Answer-1. activated tumor infiltrating
lymphocytes attack tumor cells
2. tumor cell death
3. also cause damage to nearby normal / healthy cells
4. release both tumor antigens & self-antigens
5. mixing effect --> T cells attack both cancer cells & normal cells
true / false
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