Exam (elaborations)
Hbss Sickle Cell Questions And Answers With Verified Solutions 100% Correct!!!
- Course
- Institution
Hbss Sickle Cell Questions And Answers With Verified Solutions 100% Correct!!!
[Show more]
Content preview
Hbss Sickle Cell Questions AndAnswers With Verified Solutions 100%
Correct!!!
Sickle Cell Syndromes
Definition - ANSWER✔✔ Group of hereditary disorders characterized by the
presence of sickle cell hemoglobin (HbS) in red blood cells
Sickle Cell Trait (SCT) - ANSWER✔✔ heterozygous inheritance of one normal cell
gene and one sickle cell hemoglobin gene (HbAS)
Individuals usually asymptomatic
Sickle Cell Disease (SCD) - ANSWER✔✔ heterozygous or homozygous inheritance
Most common genotypes - ANSWER✔✔ HbSS
HbSC
HbSβ+-thal
What is a primary difference between SCT and SCD in tropical regions? -
ANSWER✔✔ SCT offers partial protection against malaria
Etiology *not impt for test* - ANSWER✔✔ Normal hemoglobin (HbA) composed
of two α chains and two β chains
Defects in β chains responsible for sickling:
, HbS: valine substituted for glutamic acid
Hemoglobin C (HbC): lysine for glutamic acid
HbS—increases hydrophobicity
Inheritance - ANSWER✔✔ Sickle Cell Anemia (SCA)—form of SCD that occurs
when patient has both genes encoding for HbS
Risk of offspring inheriting disease depends upon carrier status of parents
β-thalassemia can be present at the same time as HbS
HbSS and HbSβ° do not have normal β-globin production
More severe disease
Pathophysiology
Normal adult RBCs contain - ANSWER✔✔ HbA
HbA₂
HbF (fetal hemoglobin)
Contains α₂γ₂ instead of α₂β₂
Switch to β production occurs just before birth
Increased production—anemia, HSCT, chemotherapy
Pathophysiology
RBC size and shape - ANSWER✔✔ H₂0 and Hb content determine MCHC (mean Hb
Conc)
Passive and active transport—regulate intracellular cation and volume contents
The benefits of buying summaries with Stuvia:
Guaranteed quality through customer reviews
Stuvia customers have reviewed more than 700,000 summaries. This how you know that you are buying the best documents.
Quick and easy check-out
You can quickly pay through credit card or Stuvia-credit for the summaries. There is no membership needed.
Focus on what matters
Your fellow students write the study notes themselves, which is why the documents are always reliable and up-to-date. This ensures you quickly get to the core!
Frequently asked questions
What do I get when I buy this document?
You get a PDF, available immediately after your purchase. The purchased document is accessible anytime, anywhere and indefinitely through your profile.
Satisfaction guarantee: how does it work?
Our satisfaction guarantee ensures that you always find a study document that suits you well. You fill out a form, and our customer service team takes care of the rest.
Who am I buying these notes from?
Stuvia is a marketplace, so you are not buying this document from us, but from seller classhub. Stuvia facilitates payment to the seller.
Will I be stuck with a subscription?
No, you only buy these notes for $11.99. You're not tied to anything after your purchase.
Can Stuvia be trusted?
4.6 stars on Google & Trustpilot (+1000 reviews)
81849 documents were sold in the last 30 days
Founded in 2010, the go-to place to buy study notes for 14 years now