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Hematology ASCP Questions And Answers With Verified Solutions Already Graded A+
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Hematology ASCP Questions And Answers With Verified Solutions Already Graded A+
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Hematology ASCP Questions AndAnswers With Verified Solutions Already
Graded A+
What is the characteristic RBC that is uniquely associated with HbSS?
A) Target cell (codocyte)
B) Sickle cell (drepanocyte)
C) Polychromatophilic cell
D) Spherocyte - ANSWER✔✔ B) Sickle Cell (drepanocyte)
The drepanocyte or sickle cell shape the red blood cell assumes when the
hemoglobin is deoxygenated and polymerizes. This is the result of the inherited
mutation in HbS whereby a polar amino acid in the beta globin chain is
substituted by a non-polar amino acid. This occurs mainly in patients who are
homozygous for this mutation (HbSS).
Although target cells can be seen in HbSS patients' blood, they are not specific to
this condition. Target cells can be seen in other hemoglobinopathies and other
anemias as well.
Polychromatophylic RBCs can be seen in their smears as well, but they can be
seen in almost all smears of patients who are compensating for anemia.
Spherocytes are rounded-up cells and are characteristic of Hereditary
Spherocytosis and other anemias but are not associated with Hb S.
Warfarin (coumarin-type anticoagulant) inhibits all the following coagulation
factors except:
A) Factor II
,B) Factor IX
C) Factor VII
D) Factor XI - ANSWER✔✔ D) Factor XI
Warfarin (coumarin-type oral anticoagulant) only inhibits vitamin K dependent
factors, Factors II, VII, IX, and X, and proteins C, S, and Z. Factor XI is not vitamin K
dependent.
What drug may be used to decrease iron levels in patients with iron overload?
A) Desferrioxamine
B) Cobalamin
C) Antibiotics
D) Eculizumab - ANSWER✔✔ A) Desferrioxamine
Desferrioxamine (DFO), an iron-chelating agent, may be used to reduce iron
overload in patients who rely on transfusions to maintain hemoglobin levels and
prevent anemia.
Cobalamin is the chemical name for Vitamin B12 and is the treatment of choice in
megaloblastic anemia related to B12 deficiency.
Antibiotics would be of no use in the treatment of iron overload.
Eculizumab is the drug of choice in the treatment of classic PNH. It is a humanized
monoclonal antibody that inhibits complement lysis.
Complaints of pain from a patient with sickle cell disease are most likely
associated with which of the following conditions/events?
,A) Hemolytic anemia
B) Infection
C) Vaso-occlusive crisis
D) Aplastic crisis - ANSWER✔✔ C) Vaso-occlusive crisis
Pain is a warning sign that is related to vaso-occlusion and life-threatening
complications.
Chronic hemolytic anemia is associated with sickle cell disease, but is the not the
cause of severe pain.
Infection can trigger vaso-occlusion, but is not the direct cause of the pain that
occurs during a vaso-occlusive crisis.
An aplastic crisis is not the cause of a vaso-occlusive crisis.
Patients who undergo urologic procedures, as well as those with genitourinary
tract diseases such as prostate cancer can sometimes be prone to diffuse
hemorrhage. A possible cause of this could be which of the following?
A) Dysfunction of platelets
B) Release of urokinases
C) Initiation of tissue factor released from endothelial cells
D) Release of PGL (a prostacyclin ) from endothelial cells - ANSWER✔✔ B) Release
of urokinases
The correct answer is the release of urokinases. In urologic procedures and
diseases, urokinases can be released, which have fibrinolytic activity and could
thus lead to excess fibrinolysis.
, Dysfunction of platelets has not specifically been found to be associated with
diseases of the genitourinary tract.
Tissue factor initiates coagulation and thus would not lead to excess bleeding but
rather prevent it.
PGL can prevent platelet aggregation but is also not associated with diseases of
the genitourinary tract.
A technologist decides to make a 1:20 dilution of cerebrospinal fluid (CSF) after
briefly evaluating a portion of the sample microscopically. After making the
dilution and charging the chambers, the number of observed cells in each of the
large squares of the hemocytometer is >100. What should the technologist do to
obtain the most accurate count?
A) Count all four corner squares.
B) Make a smaller dilution
C) Make a larger dilution.
D) No dilution is necessary. - ANSWER✔✔ C) Make a larger dilution
The best choice would be to make a larger dilution before performing the cell
count. This will provide the most accurate results.
Laboratory results obtained on a 47-year-old patient were as follows:
WBC 51.2 x 103/µL
RBC 4.27 x 106/µL
HGB 12.6 g/dL
HCT 36.9%
PLT 403 x 103/µL
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