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Advanced Pharmacology Exam 1 questions with verified answers
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Advanced Pharmacology Exam 1 questions with verified answers
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Advanced Pharmacology Exam 1 questionswith verified answers
Once myou mgraduate mfrom man mNP mprogram, min morder mto mprescribe myou'll mneed: m-
mANSWER: m m➡ m-Advanced mnurse mprescriber mlicense
-DEA m#
What mis mthe mpurpose mof ma mDEA m#? m- mANSWER: m m➡ mNeeded mto mprescribed mscheduled
mdrugs
Rules mfor mprescribing mSchedule mII mdrugs: m- mANSWER: m m➡ m-Written mscript mneeded
-1 mmonth msupply monly m
-No mrefills
What mis mthe mPDMP? m- mANSWER: m m➡ mPrescription mDrug mMonitoring mProgram
Used mto meffectively mtrack mpatient's mcontrolled msubstance muses macross mdifferent mhealth
mfacilities m(in mthe msame mstate)
What mare mclinical mpractice mguidelines? m- mANSWER: m m➡ mRecommendations mthat mare
mintended mto moptimize mpatient mcare mthat mare minformed mby ma msystematic mreview mof mthe
mevidence mand man massessment mof mthe mbenefits/harms mof malternative mcare mpractices
Ex: msepsis, mCAP
Common mcauses mof mmedication merrors: m- mANSWER: m m➡ m-Illegible mwriting
-Drug mnames mthat msound malike
-Medications mthat mlook malike
,-Administering ma mdrug mwith mthe mwrong mroute
What mis mpharmacokinetics? mWhat mare mits m4 mcategories? m- mANSWER: m m➡ mWhat mthe mbody
mdoes mto mthe mdrug
1. mAbsorption
2. mMetabolism
3. mDistribution
4. mExcretion
Quickest mroute mof mabsorption? mSlowest? m- mANSWER: m m➡ mIV m= mquickest m
IM m= mslowest
What mis mthe mmost mcommon mway mdrugs mpass mthrough mcell mmembranes? m- mANSWER: m m➡
mPassive mdiffusion
What mcharacteristics mof ma mdrug mallow mit mto mpass mmost mquickly mthrough mcell mmembranes
m(usually mthrough mpassive mdiffusion)? m- mANSWER: m m➡ mSmall, muncharged m(unionized),
mlipid msoluble--pass mthrough mmembrane mwithout many menergy
What mdoes mit mmean mwhen ma mdrug mis mionized? m- mANSWER: m m➡ mIt mmeans mthat mthe mdrug
mis mstuck min mthe mcompartment mit mwas mionized min mand mhas mto mbe mmoved mto mthe mnext
mcompartment m(cannot mbe mabsorbed minto mthe mbloodstream)
Where mdo mweak macids mabsorb? m- mANSWER: m m➡ mStomach
Where mdo mweak mbases mabsorb? m- mANSWER: m m➡ mSmall mintestine
pH mof mstomach: m- mANSWER: m m➡ m2-4
,pH mof msmall mintestine: m- mANSWER: m m➡ m6-7
pH mof mlarge mintestine: m- mANSWER: m m➡ m6-7
pH mof mbloodstream: m- mANSWER: m m➡ m7.35-7.45
pH mof mbladder: m- mANSWER: m m➡ m5-8
pH mof mbreastmilk: m- mANSWER: m m➡ m7.1
Where mwill ma mdrug mabsorb mif mit mis ma mweak mbase mthat mionizes mat ma mpH mof m4 mand mlower? m-
mANSWER: m m➡ mIn mthe msmall mintestine m(since mthe mstomach mhas ma mpH mof m2-4, mso mthe mdrug
mwill mbecome mionized mand mmove mto mthe msmall mintestine mwhere mit mwill mbe mable mto mabsorb
minto mthe mbloodstream)
How mcan mwe mmanipulate mthe murine mpH min mcases mof moverdose? m- mANSWER: m m➡ mDrugs
mthat mare mweak macids m(aspirin) mcan mbe mtrapped mand mexcreted mthrough mthe murine. m
We mraise mpH mof mthe murine m(with msodium mbicarb) mto mforce mthe mdrug mto mionize mand mallow
mit mto mbe mexcreted, mnot mreabsorbed mthrough mthe mbloodstream.
What mis mdistribution? m- mANSWER: m m➡ mHow ma mdrug mwill mbe mtransported mto mthe mtissues
mit mneeds mto mgo mto min morder mfor mit mto mexert mits meffects
Drug mfactors mrelated mto mdistribution: m- mANSWER: m m➡ m-Lipid msolubility m
-Molecular msize
-Degree mof mionization m
-Duration mof maction
, -Cellular mbinding
-Therapeutic meffects m
-Toxic meffects
(lipid msoluble, msmall, mand mnon-ionized mdrugs mwill mdistribute mmore mquickly)
Body mfactors mrelated mto mdistribution: m- mANSWER: m m➡ m-Vascularity m(poor mperfusion,
mdisruption mof mblood mflow mdue mto mtrauma--difficulty mdistributing)
-Blood mbarriers m(blood-brain-barrier mcan mbe mproblematic mif mwe mneed mto mget mdrugs mto
mthe mbrain--will mneed mvery mhigh mdosing msince monly ma msmall mamount mof mthe mdrug mwill mget
mthrough)
-Transport mmechanisms m
-Plasma mbinding mproteins m
-Disease mstates
-Volume mof mdistribution
-Drug minteractions
What mis mthe mkey mplasma mprotein minvolved mwith mprotein mbinding mfor mmedications? m-
mANSWER: m m➡ mAlbumin
Why mdo mwe mmonitor malbumin? m- mANSWER: m m➡ mIndicative mof mnutritional mstatus mand
mhow mwell mprotein-bound mdrugs mwill mbe mtransported mto mtheir mtarget mlocations
What mhappens mto mthe mtherapeutic meffect mof ma mdrug mwhen mthe mpatient mis melderly mand mhas
mvery mlow mlevels mof malbumin? m- mANSWER: m m➡ mThe mdrug mdoes mnot mbind mto mthe mprotein
m(albumin) mas mmuch mas mexpected, mso mthere mis ma mlot mof mfree mdrug mfloating min mthe mplasma;
mhigh mrisk mfor mdrug mtoxicity
Protein mbound mmeans: m- mANSWER: m m➡ mInactive mform mof mthe mdrug; mdoes mnot mhave many
mtherapeutic meffect mwhen mbound mto ma mprotein
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