What process creates the variable region domain for both TCRs and BCRs? - Somatic
Recombination
What the different types IFN-1? - Alpha and Beta
What are the differences and similarities between CD8 T Cells and NK cells? - The both have the
same cytotoxic granules, NK cells are activated faster...
PCB 3233 - Immunology Exam 3
What process creates the variable region domain for both TCRs and BCRs? - Somatic
Recombination
What the different types IFN-1? - Alpha and Beta
What are the differences and similarities between CD8 T Cells and NK cells? - The both have the
same cytotoxic granules, NK cells are activated faster, because they come out of the bone marrow "ready
to go". CD8 T cells recognizes MHC Class 1 + peptide (antigen) on a pathogen, while NK cells recognize
normal MHC Class 1 molecules on the surface of our cells and activating ligands that infected cells put up
on their surface.
2 types of activating ligands - MIC - A and MIC - B, they bind to activating receptors on activating
NK cells
Type 2 interferon - Also know as IFN- gamma, activates macrophages
IL - 12 - Inflammatory cytokine that activates NK cells which then produces IFN - gamma which
then activate macrophages.
Which complement receptors can recognize C3b? - CR 1 - CR 4
Which Professional Antigen Presenting Cell (Professional - APC) is strong enough to activate a CD8 T cell
from a naive state? - Dendritic cells
C3 convertase of the Alternative Pathway - C3bBb
When will NK cells make interferon gamma? - When they are activated by IL-12 (inflammatory
cytokine)
, Explain the activation of macrophage feedback loop - NK cells become activated by IL- 12, they
produce interferon gamma, IFN- gamma activates macrophages, macrophages secrete IL-12 (+ other
cytokines)
Helper T cells associate with which class of MHC molecules? - MHC Class 2 (extracellular infection)
Interferon function - Viral fighting, they activate NK cells which then tell our infected cells to die
by apoptosis.
Describe the chains in a TCR? - V region followed by a C region followed by a membrane
anchoring domain
Where is the most variable region of the TCR? - V-alpha and V- beta
CDR - area of hypervariability condensed in loops in domain farthest from the T cell membrane
How many CDRs does each TCR chain have? - 3, CDR 1 - 3
How many binding sites do TCRs have? - 1 binding site for antigen
Function of T cells - to recognize antigen
What part in T cells handles the mediating effector functions? - the proteins produced by the T
cells
Alpha Chain Chromosome - Chromosome 14
Beta Chain Chromosome - Chromosome 7
What happens during T cell development? - Somatic DNA recombination, alpha chain = V+J, beta
= (D+J) + V
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