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PCB 3233 EXAM 2 Questions And Answers Graded A+ $7.99   Add to cart

Exam (elaborations)

PCB 3233 EXAM 2 Questions And Answers Graded A+

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  • PCB 3233
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  • PCB 3233

What are the external TLRs - TLR-5:Bacterial Flagellin TLR-4:Bacterial LPS TLR-3 recognizes? - Double stranded Viral RNA TLR-7 recognizes? - Single stranded Viral RNA TLR-5 recognizes? - bacterial flagellin TLR-4 recognizes? - Bacterial LPS Leukocytes in the order to action - 1. Neutrophils -...

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  • August 12, 2024
  • 23
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • PCB 3233
  • PCB 3233
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ACADEMICMATERIALS
PCB 3233 EXAM 2
What are the external TLRs - TLR-5:Bacterial Flagellin

TLR-4:Bacterial LPS



TLR-3 recognizes? - Double stranded Viral RNA



TLR-7 recognizes? - Single stranded Viral RNA



TLR-5 recognizes? - bacterial flagellin



TLR-4 recognizes? - Bacterial LPS



Leukocytes in the order to action - 1. Neutrophils - Mass quantities

2. Monocytes

3.Lymphocytes - days later



2 cell type recognition - 1. NK - looking at your own cells

2. Macrophages - looking at pathogen directly



Macrophages - use toll like receptors and phagocytic receptors



PAMP - pathogen associated molecular patterns - on pathogen



PRR - pattern recognition receptors - on leukocyte



Are there different receptor used for phagocytosis vs. cytokine creation and secretion(signalling)? -
yes

,What are the 5 cytokines? - IL-1

TNF-a

IL-6

CXCL8

IL-12



Which cytokines are pyrogens? - IL-1

TNF-a

IL-6



What do heat cytokines (Pyrogens) lead to? - Lead to fever



Which cytokines activate endothelial cells? - IL-1 and TNF-a



What does the activation of endothelial cells lead to? - Vasodilation and Vascular premeability



NK cells provides an early response for which kind of infection? - Viral Infection



NK recognizes two types of receptors - Activating receptors and inhibitory receptors



Activating receptors recognize - (Stress induced) activating ligands which leads to apoptosis.



Inhibitory receptors recognizes - MHC 1 on all nucleated cells.



1st effector cell - Resident Macrophages which is prevalent in connective tissues



CR1 (complement receptor 1) binds to? - C3b

, C3b is degraded by what to become iC3b? - Factor I



NK cells can detect? - MHC molecules



Which receptor can recognize both Gram(-) and Gram(+)? - Scavenger Receptor A (SR-A)



Which leukocyte would be first out to the sight of infection in mass quantities? - Neutrophils



Macrophages Receptors (PRR): - Mannose Receptor

CR-3

CR-4

Dectin-1

SR-A (Scavenger Receptor-A)

SR-B (Scavenger Receptor - B)

LPS (also known as CD14)

TLR

MARCO



Can all nucleated cells use MHC 1? - yes



Macrophages are longlived compared to what? - Neutrophils

Induced innate immune response - -Inflammation

-Leukocytes called into the site of infection

-Soluble molecules made and secreted into the blood and brought to the site of the infection




What can CR1 do for you? - Bind to C3b and phagocytose what ever C3b is bound to

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