Immunodeficiencies Exam; Questions &
Answers 100% Correct
Which primary immunodeficiency mainly impacts B cell development without affecting T cells?
Answer-X-linked agammaglobulinemia (XLA)
Individuals with X-linked agammaglobulinemia (XLA) are more susceptible to some kinds of
pathogens ...
Immunodeficiencies Exam; Questions &
Answers 100% Correct
Which primary immunodeficiency mainly impacts B cell development without affecting T cells?
Answer-X-linked agammaglobulinemia (XLA)
Individuals with X-linked agammaglobulinemia (XLA) are more susceptible to some kinds of
pathogens than others. What pathogen do you think an XLA patient would be LEAST susceptible
to? Answer-intracellular bacterium
M. tuberculosis is the only intracellular pathogen listed in the answers above. XLA is a deficiency
of antibodies, which function almost exclusively outside of cells. Individuals with XLA have an
increased frequency of S. aureus, S. pneumoniae, and G. lamblia infections. XLA patients are
more susceptible to mycobacterial infections, but these infections are much less frequent in XLA
patients than infections with the other pathogens listed above.
The number of B lymphocytes and T lymphocytes in the blood is an important component of
the clinical diagnosis of primary immunodeficiencies. Which disorder would be most likely to
lead to low blood counts of T cells and B cells? Answer-RAG type SCID
Which of these factors does NOT contribute to the generation of self-reactive T cells?
Answer-millions of different inherited T cell receptor genes
Which of the following is a mechanism of peripheral tolerance that controls self-reactive
effector B cells AND self-reactive effector T cells? Answer-regulatory T cell suppression
, Immunodeficiencies Exam; Questions &
Answers 100% Correct
What is the main difference between central tolerance in the thymus and in the bone marrow?
Answer-Clonal deletion of T cells occurs in the thymus, while receptor editing of B cells
occurs in the bone marrow. correct
How do antibodies contribute to glomerulonephritis in lupus? Answer-Antibodies form
immune complexes, which cause inflammation that damages kidney vessels. correct
How do antibodies contribute to myasthenia gravis? Answer-Antibodies neutralize a key
molecule involved in neuron function
Monozygotic (identical) twins are approximately 50% concordant for type 1 diabetes (T1D). This
means that if one twin has T1D, there is about a 50% chance that the other twin will also have
the disease. T1D is not a common disease. This suggests that Answer-T1D risk is
determined partially by genetic factors and partially by environmental factors.
What distinguishes allergy from autoimmunity? Answer-Allergy is a response to
environmental antigens; autoimmunity is a response to self antigens. correct
Some "type 2" T follicular helper cells secrete IL-4 and IL-13. In response, B cells initiate class
switching that favors the ___________ isotype, which plays a particularly important role in
allergy. Answer-IgE
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