Oncology Medications - Test 1 - Concepts
3 - CCBC Essex RN QUESTIONS AND
ANSWERS
1. What are alkylating agents (cell cycle, mode of action, type of
cancers)?: Non cell cycle specific because can affect cells in resting
phase React chemically with RNA, DNA & other proteins; treatment
of slow growing cancers
2. What are pharmacological examples of alkylating agents?:
Cyclophosphamide, Ifosfamide, Cisplatin
3. What are Antimetabolites (cell cycle, mode of action, type of
cancers)?: Inhibit DNA production in cells that depend on certain
natural metabolites to produce their DNA (S phase specific) Treat
leukemia, GI, & Basal Cell Cancers Replace needed metabolites and
prevent normal cellular function
4. What are pharmacological examples of Antimetabolites?:
Methotrexate, Fluorouracil
5. What are Antineoplastic Antibiotics (cell cycle, mode of action, type
of cancers)?: Selective for bacterial cells but toxic to human cells
6. What are pharmacological examples of Antineoplastic Antibiotics?:
Doxorubicin, Bleomycin
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, 7. What are Mitotic Inhibitors (cell cycle, mode of action, type of
cancers)?: Drugs that kill cells as the process of mitosis begins; inhibit
DNA synthesis
8. What is a pharmacologic example of Mitotic Inhibitors?: Vincristine
9. Cyclophosphamide Drug class: alkylating agent
10. Cyclophosphamide side effects: Hemorrhagic cystitis is fatal side
effect - 2-3 litres of water a day needed
13. Ifosfamide Drug class: alkylating agent
14. Ifosfamide side effects: Hemorrhagic cystitis is fatal side effect - 2-3
litres of water a day needed
15. Ifosfamide cancers treated: combo for testicular cancer
16. Ifosfamide cytoprotective agent: Mesna
17. Cisplatin Drug Class: alkylating agent
18. Cisplatin side effects: nephrotoxicity and ototoxicity. 2-3 liters
hydration daily and Baseline hearing screening
19. Cisplatin cancers treated: Combo therapy for metastatic testicular or
ovarian tumors
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