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HMX Pharmacology Definitions – Complete Guide

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  • HMX Pharmacology
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  • HMX Pharmacology

HMX Pharmacology Definitions – Complete Guide

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  • August 8, 2024
  • 13
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • HMX Pharmacology
  • HMX Pharmacology
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LeCrae
HMX Pharmacology Definitions – Complete Guide

The uptake of a drug from its site of administration into the bloodstream.
Right Ans - Absorption

The movement of a molecule against its concentration gradient across a
membrane, with a concomitant expenditure of energy. Right Ans - Active
transport

A measure of the strength of drug-receptor binding. Right Ans - Affinity

An endogenous or exogenous ligand that binds to and stimulates a receptor to
produce a molecular response. Right Ans - Agonist

A reaction involving synthesis of new molecules, generally requiring energy
Right Ans - Anabolic reaction

An endogenous or exogenous molecule that binds to and blocks a receptor to
inhibit a molecular response. Right Ans - Antagonist

A glycoprotein that plays an important role in the immune response by
binding to and targeting specific antigens for removal from the body Right
Ans - Antibody

A substance, generally foreign to the body, that induces an immune response.
Right Ans - Antigen

When the concentration of drug in the plasma is plotted over time on a graph,
the AUC is used as a measure of the total exposure of the body to a drug.
Right Ans - Area under the curve (AUC)

Specialized glial cells in the brain that contribute to the integrity of the blood-
brain barrier. Right Ans - Astrocytes

The molecular response produced by a receptor in the absence of a bound
ligand, also referred to as constitutive activity. Right Ans - Basal activity

, A graph representing the percentage of receptor occupancy, or the percentage
of receptors bound by a drug, plotted against the concentration of drug at the
receptor. Right Ans - Binding curve

Therapeutics that are large in size (biological polymers), have complex
structures, and are derived from natural sources. Right Ans - Biologics

A protective membrane barrier between the blood and the brain that consists
of endothelial cells joined by tight junctions and surrounded by astrocytes.
Right Ans - Blood-brain barrier

A concentration corresponding to half the maximal concentration of drug in
the bloodstream. Right Ans - C50

A therapy that involves introducing live cells into a patient. These cells can be
obtained from the patient or another individual, and may be modified
genetically or developmentally before use. Right Ans - Cell-based therapy

A protein found within a cell or cell membrane such as a receptor, an enzyme,
an ion channel, or a transporter. Right Ans - Cellular protein

The process of determining the biological, chemical, toxic, and
pharmacological properties of a compound during drug development.
Right Ans - Characterization (of a compound)

The volume of plasma cleared of a drug in a unit of time. Right Ans -
Clearance

The maximum concentration of drug achieved in the bloodstream. Right
Ans - Cmax

An antagonist that binds to a receptor, thereby inhibiting the binding of an
agonist to that receptor and preventing a molecular response from being
produced by the agonist. Right Ans - Competitive antagonist

Drug discovery that begins by identifying a compound. Right Ans -
Compound-centered drug discovery

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