NUR 410 Exam 1 Questions with Correct Answers
Lupus (SLE) defined Correct Answer-Chronic inflammatory, multi-
system disorder of connective tissue
- autoimmune origin
- genetic influence
- environmental factor
- drug induces
- flare ups & remission (may not go back to baseline)
- no way to predict its progression
- variable
Lupus (SLE) patho Correct Answer-production of large variety of
autoantibodies which results from hyperactivity of B-cells (protect from
non-self) as a result of a disordered T-cell function - antibodies form
immune complexes which are deposited into CT which then prompt
inflammatory response leading to local tissue damage
Lupus (SLE) leading causes of death Correct Answer-1. Renal failure
2. Cardiac failure
3. Neuro
Lupus (SLE) risk factors Correct Answer-- genetic influence (HLA
genes)
- women childbearing age (high estrogen)
- first symptoms seen at menarche
- more common in African Americans, Asians & Hispanic
- environmental factors (EBV: mono)
- drug induced
Lupus (SLE) clinical manifestations Correct Answer-- extremely
variable in severity
- recurring remission & exacerbation
- no characteristic pattern of organ involvement
,- most commonly affects: skin, muscle, kidney, lining of lungs, gut,
heart, nervous tissue
Generally: fever, weight loss, anorexia, malaise, excessive fatigue may
proceed exacerbation - usually feel 10x when an exacerbation is coming
- exacerbations more common in spring & summer (pollen & vacay)
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