Pharmacology - Antidepressants; Questions &
Answers 100% Solved
What is the mechanism of action of tricyclic antidepressants? Correct answer-They block
the reuptake of both norepinephrine and serotonin
What are the potential side effects of TCA's? Correct answer-Anticholinergic effects
(uri...
Pharmacology - Antidepressants; Questions &
Answers 100% Solved
What is the mechanism of action of tricyclic antidepressants? Correct answer-They block
the reuptake of both norepinephrine and serotonin
What are the potential side effects of TCA's? Correct answer-Anticholinergic effects
(urinary retention, constipation, tachycardia, dry mouth, and blurred vision), sedation, sexual
dysfunction, orthostatic hypotension, hyperpyrexia, and confusion and hallucinations in the
elderly
What happens when a patient has overdosed on TCA's? Correct answer-Arrhythmias with
QRS prolongation, cardiotoxicity, coma, and convulsions
What are some common TCA's? Correct answer-amitriptyline (Elavil), desipramine
(Norpramin), nortriptyline (Pamelor), clomipramine, imipramine, and doxepin
What is serotonin syndrome? Correct answer-It is a hypertensive crisis, with delirium,
hyperpyrexia, convulsions. It occurs when multiple drugs that affect serotonin levels are used at
the same time: for example MAOI's combined with SSRI's
What is the mechanism of action of amitriptyline? Correct answer-It is a TCA, so it
inhibits reuptake of norepinephrine and serotonin
What are the side effects of SSRI's? Correct answer-GI upset, head aches, insomnia,
sweating, and sexual dysfunction
What are the indications for SSRI use? Correct answer-Depression, panic disorders (DOC),
obsessive compulsive disorder (might need higher doses), social anxiety disorder, and PTSD
True or false: a patient who does not respond to one SSRI might respond to another
Correct answer-True.
What is the mechanism of action of desipramine? Correct answer-It is a TCA, so it inhibits
the reuptake of norepinephrine and serotonin
What is the mechanism of action of paroxetine? Correct answer-It is a SSRI, so it inhibits
the reuptake of serotonin at the presynaptic neuron
What is the mechanism of action of citalopram? Correct answer-It is a SSRI, so it inhibits
the reuptake of serotonin at the presynaptic neuron
What are some common SSRI's? Correct answer-citalopram (Celexa), escitalopram
(Lexapro), sertraline (Zoloft), paroxetine (Paxil), fluoxetine (Prozac), fluvoxamine (Luvox)
What is the mechanism of action of trazodone (Oleptro)? Correct answer-It decreases
reuptake of serotonin only.
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