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Tricyclic Antidepressants; Questions & Answers 100% Solved

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  • Antidepressants;

Tricyclic Antidepressants; Questions & Answers 100% Solved What neurotransmitters do TCAs inhibit reuptake of into the presynaptic neuron? Correct answer-Norepinephrine and serotonin. If discovered today, what class of antidepressants might TCAs have been referred to as? Correct answer-SNR...

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  • August 8, 2024
  • 5
  • 2024/2025
  • Exam (elaborations)
  • Questions & answers
  • Antidepressants;
  • Antidepressants;
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Tricyclic Antidepressants; Questions &
Answers 100% Solved
What neurotransmitters do TCAs inhibit reuptake of into the presynaptic neuron? Correct
answer-Norepinephrine and serotonin.




If discovered today, what class of antidepressants might TCAs have been referred to as?
Correct answer-SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors).




What distinguishes TCAs from SNRIs despite their similar mechanism of action? Correct
answer-TCAs have different adverse effects relative to SNRIs.




Name the tertiary amine that serves as the prototype drug for TCAs. Correct answer-
Imipramine




Which TCAs are classified as secondary amines? Correct answer-Desipramine and
nortriptyline.



What are the N-demethylated metabolites of imipramine and amitriptyline, respectively?
Correct answer-Desipramine (of imipramine) and nortriptyline (of amitriptyline).




Name two related "tetracyclic" antidepressant agents that are commonly included in the
general class of TCAs. Correct answer-Maprotiline and amoxapine.

, Tricyclic Antidepressants; Questions &
Answers 100% Solved
What neurotransmitter reuptake do TCAs and amoxapine inhibit? Correct answer-
Norepinephrine and serotonin.




Besides TCAs, which specific agents are relatively selective inhibitors of norepinephrine
reuptake? Correct answer-Maprotiline and desipramine.




Apart from inhibiting neurotransmitter reuptake, what other receptors do TCAs block?
Correct answer-Serotonergic, α-adrenergic, histaminic, and muscarinic receptors.




What is likely responsible for many of the adverse effects of TCAs? Correct answer-
Actions at serotonergic, α-adrenergic, histaminic, and muscarinic receptors.




Besides serotonin receptors, what other receptors does amoxapine block? Correct
answer-Amoxapine also blocks 5-HT2 and dopamine D2 receptors.




What are the actions of TCA's? Correct answer-TCAs improve mood, in 50% to 70% of
individuals with major depression.




How long does it take for TCA's to start working? Correct answer-2 weeks or longer




Why is tapering doses recommended in TCA's? Correct answer-To minimize
discontinuation syndromes and cholinergic rebound effects.

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